Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress
المؤلفون المشاركون
Zhang, Li
Yang, Danfeng
An, GaiHong
Chen, XueWei
Li, Chao
Wei, MengFan
Chen, JiaJun
Ma, Qiang
Wang, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High-temperature exposure is detrimental to women’s reproductive health; however, the impact caused by long-term high temperature is not comprehensive, and a stable model of estrous cycle disorder induced by a high temperature is yet lacking.
Herein, we aimed to establish a stable and effective model of estrous cycle disorder in female rats induced by long-term heat stress to study its physiological and pathological characteristics and explore the underlying mechanism.
In the present study, female Sprague-Dawley rats with normal estrous cycles were exposed to the temperature of 38±0.5°C, relative humidity (RH) of 55±5% (2 h/d, 1 time/d) hot cabin at more than 90 days.
Consequently, after long-term heat stress, no difference was detected in body weight and rectal temperature, but the estrus cycle was prolonged, the uterine organ index was increased, pathological changes occurred, the increase latitude of stress hormones heat shock protein 70 (Hsp70) and corticosterone (CORT) decreased, estradiol (E2) and luteinizing hormone (LH) levels decreased, follicle stimulating hormone (FSH) and prolactin (Prl) levels increased, gonadotropin-releasing hormone (GnRH) and thyroid hormone (T4) showed no difference, and insulin (INS) decreased significantly.
Moreover, the mRNA expression of the sex hormone receptor in the uterus and ovary was altered.
Therefore, the estrous cycle disorder in female rats can be induced by regular heat stress for 90 days, which can be considered the pioneer method.
Subsequently, prominent physiological and pathological characteristics and disruption in the hypothalamic-pituitary-gonadal (HPG) axis were noted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
An, GaiHong& Chen, XueWei& Li, Chao& Zhang, Li& Wei, MengFan& Chen, JiaJun…[et al.]. 2020. Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
An, GaiHong…[et al.]. Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
An, GaiHong& Chen, XueWei& Li, Chao& Zhang, Li& Wei, MengFan& Chen, JiaJun…[et al.]. Pathophysiological Changes in Female Rats with Estrous Cycle Disorder Induced by Long-Term Heat Stress. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر