X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

الملخص EN

Purpose.

To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT).

Design.

Retrospective, observational study.

Methods.

Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016.

Each eye was measured by SD-OCT using the same clinical protocol.

A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed.

Results.

Six patients demonstrated retinoschisis (12 eyes) and typical foveal cyst-like cavities (10 eyes) on SD-OCT images with a mean logMAR VA of 0.48.

The median age was 7.5 years at the initial visit.

Their foveal retinal thickness (516.9 μm) and choroid thickness (351.4 μm) decreased at a rate of 38.1 and 7.5 μm, respectively, at the 10.5-month follow-up visit; however, there were no significant differences (P=0.622 and P=0.406, resp.).

There was no significant correlation between VA, the foveal retinal thickness, and subfoveal choroid thickness.

Conclusions.

SD-OCT images for XLRS patients during the juvenile period revealed no significant changes in the fundus structure, including the foveal retinal thickness and choroid thickness within one-year follow-up.

There was a lack of correlation between VA, foveal retinal thickness, and subfoveal choroid thickness.