A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness
المؤلفون المشاركون
Cataldi, Angel Adrián
Blanco, Federico Carlos
Sasiain, María del Carmen
Lima, Analía
Bei, Jinlong
Bigi, María Mercedes
Zhang, Qi
Yu, Ting
Wang, Zhilin
Dai, Zhangyan
Chen, Zhuang
Bigi, Fabiana
Duran, Rosario
López, Beatriz
de la Barrera, Silvia S.
Ritacco, Viviana
Soria, Marcelo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Tuberculosis (TB) is an infectious disease, caused by Mycobacterium tuberculosis, primarily affecting the lungs.
The M.
tuberculosis strain of the Haarlem family named M was responsible for a large multidrug-resistant TB (MDR-TB) outbreak in Buenos Aires.
This outbreak started in the early 1990s and in the mid 2000s still accounted for 29% of all MDR-TB cases in Argentina.
By contrast, a clonal variant of strain M, named 410, has caused a single tuberculosis case since the onset of the outbreak.
The molecular bases of the high epidemiological fitness of the M strain remain unclear.
To assess its unique molecular properties, herein, we performed a comparative protein and lipid analysis of a representative clone of the M strain (Mp) and the nonprosperous M variant 410.
We also evaluated their growth in low pH.
The variant 410 had higher levels of latency proteins under standard conditions and delayed growth at low pH, suggesting that it is more sensitive to stress stimuli than Mp.
Moreover, Mp showed higher levels of mycolic acids covalently attached to the cell wall and lower accumulation of free mycolic acids in the outer layer than the 410 strain.
The low expression of latency proteins together with the reduced content of surface mycolic acids may facilitate Mp to evade the host immune responses.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bei, Jinlong& Bigi, María Mercedes& Lima, Analía& Zhang, Qi& Blanco, Federico Carlos& López, Beatriz…[et al.]. 2020. A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bei, Jinlong…[et al.]. A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bei, Jinlong& Bigi, María Mercedes& Lima, Analía& Zhang, Qi& Blanco, Federico Carlos& López, Beatriz…[et al.]. A Phenotypic Characterization of Two Isolates of a Multidrug-Resistant Outbreak Strain of Mycobacterium tuberculosis with Opposite Epidemiological Fitness. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر