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Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?
المؤلفون المشاركون
Tarčuković, Janja
Valenčić, Lara
Polonijo, Željka
Fućak, Ana
Dangubić, Boban
Grubješić, Igor
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-12-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Tumour lysis syndrome (TLS) is a group of pathophysiological processes caused by rapid degradation of tumour cells with subsequent release of intracellular contents into the extracellular space.
It is characterized by the development of systemic metabolic disturbances with or without clinical manifestations.
The process usually occurs in highly proliferative, large tumours after induction of cytotoxic therapy.
Rarely, however, spontaneous TLS can develop, as well as signs of multiorgan failure triggered by an excessive metabolic load and sterile inflammation.
The combination of the aforementioned is thus quite unique.
Here, we present a 63-year-old male in which spontaneous TLS was accompanied with acute liver failure and delineated underlying nonHodgkin lymphoma.
Initial laboratory findings included hyperkalaemia, hyperphosphataemia, hypocalcaemia, uraemia, and increased creatinine levels indicating the onset of TLS with acute kidney injury.
Moreover, the patient showed signs of jaundice, coagulopathy, and hepatic encephalopathy.
Development of TLS with multiorgan failure prompted rapid initiation of critical care management, including vigorous intravenous fluid therapy, allopurinol treatment, high flow continuous venovenous haemodiafiltration, and commencement of chemotherapy.
The case highlights the possibility of TLS as a differential diagnosis in patients presenting with multiorgan failure and the importance of early detection of this potentially challenging and fatal diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tarčuković, Janja& Valenčić, Lara& Polonijo, Željka& Fućak, Ana& Dangubić, Boban& Grubješić, Igor. 2019. Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?. Case Reports in Critical Care،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1134173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tarčuković, Janja…[et al.]. Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?. Case Reports in Critical Care No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1134173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tarčuković, Janja& Valenčić, Lara& Polonijo, Željka& Fućak, Ana& Dangubić, Boban& Grubješić, Igor. Acute Liver Failure as the Leading Manifestation of Spontaneous Tumour Lysis Syndrome in a Patient with NonHodgkin Lymphoma: Do Current Diagnostic Criteria of Tumour Lysis Syndrome Need Re-Evaluation?. Case Reports in Critical Care. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1134173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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