The Roles of Uterine Natural Killer (NK) Cells and KIRHLA-C Combination in the Development of Preeclampsia: A Systematic Review
المؤلفون المشاركون
Meng, Tao
Yang, Xiuhua
Yang, Yahui
Yuan, Yiru
Liu, Lin
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-03-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Preeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear.
It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby causing failed placentation and producing inflammatory factors.
The decline of blood flow results in lowering the nutrients and oxygen received by the fetus and augmenting the placental pressure in PE.
Decidual immune cells, especially uterine natural killer (uNK) cells, are involved in the process of placentation.
Decidual NK (dNK) cells significantly contribute to the vascular remodeling through the secretion of cytokines and angiogenic mediators in normal placental development.
The abnormal activation of NK cells in both the peripheral blood and the decidua was counted among the causes leading to PE.
The correlation existing between maternal killer cell immunoglobulin-like receptor (KIR) and HLA-C in trophoblast cells constitutes a robust evidence for the genetic etiology of PE.
The combinations of the two kinds of gene systems, together with the KIR genotype in the mother and the HLA-C group in her fetus, are likely to exactly decide the pregnancy outcome.
The women, who have the inappropriate match of KIR/HLA-C, are likely to be prone to the augmented risk of PE.
However, the combinations of KIR/HLA-C in PE undergo ethnic changes.
The extensive prospective research works in Europe, Asia, and Africa are required for providing more findings in PE patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiuhua& Yang, Yahui& Yuan, Yiru& Liu, Lin& Meng, Tao. 2020. The Roles of Uterine Natural Killer (NK) Cells and KIRHLA-C Combination in the Development of Preeclampsia: A Systematic Review. BioMed Research International،Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiuhua…[et al.]. The Roles of Uterine Natural Killer (NK) Cells and KIRHLA-C Combination in the Development of Preeclampsia: A Systematic Review. BioMed Research International No. 2020 (2020), pp.1-10.
https://search.emarefa.net/detail/BIM-1134221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiuhua& Yang, Yahui& Yuan, Yiru& Liu, Lin& Meng, Tao. The Roles of Uterine Natural Killer (NK) Cells and KIRHLA-C Combination in the Development of Preeclampsia: A Systematic Review. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-10.
https://search.emarefa.net/detail/BIM-1134221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر