Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R--) Mice via Its Anti-inflammatory and Antipyroptotic Effects
المؤلفون المشاركون
Dong, Min
Pei, Zuo-Wei
Zhu, Huo-Lan
Wang, Fang
Guo, Ying
Zhang, Qian
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hyperlipidemia is a risk factor for cardiac damage and cardiovascular disease.
Increasing evidence has shown that dyslipidemia-related cardiac damage is associated with lipid accumulation, oxidative stress, and inflammation.
Thymoquinone (TQ) is the major constituent of Nigella sativa, commonly known as black seed or black cumin, and is globally used in folk (herbal) medicine for treating and preventing a number of diseases and conditions.
Several studies have shown that TQ can protect against cardiac damage.
This study is aimed at investigating the possible protective effects of TQ on hyperlipidemia-induced cardiac damage in low-density lipoprotein receptor-deficient (LDL-R-/-) mice.
Eight-week-old male LDL-R-/- mice were randomly divided into normal diet (ND), high-fat diet (HFD), and HFD and TQ (HFD+TQ) groups and were fed the different diets for eight weeks.
Blood samples were obtained from the inferior vena cava in serum tubes and stored at -80°C until use.
Some cardiac tissues were fixed in 10% formalin and then embedded in paraffin for histological evaluation.
The remainder of the cardiac tissues was snap-frozen in liquid nitrogen for mRNA preparation or immunoblotting.
The levels of metabolism-related factors, such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and high-sensitivity C-reactive protein (hs-CRP), were decreased in the HFD+TQ group compared with those in the HFD group.
Periodic acid-Schiff staining demonstrated that lipid deposition was lower in the HFD+TQ group than in the HFD group.
The expression of pyroptosis indicators (NOD-like receptor 3 (NLRP3), interleukin- (IL-) 1β, IL-18, and caspase-1), proinflammatory factors (IL-6 and tumor necrosis factor alpha (TNF-α)), and macrophage markers (cluster of differentiation (CD) 68) was significantly downregulated in the HFD+TQ group compared with that in the HFD group.
Our results indicate that TQ may serve as a potential therapeutic agent for hyperlipidemia-induced cardiac damage.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pei, Zuo-Wei& Guo, Ying& Zhu, Huo-Lan& Dong, Min& Zhang, Qian& Wang, Fang. 2020. Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R--) Mice via Its Anti-inflammatory and Antipyroptotic Effects. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134279
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pei, Zuo-Wei…[et al.]. Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R--) Mice via Its Anti-inflammatory and Antipyroptotic Effects. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1134279
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pei, Zuo-Wei& Guo, Ying& Zhu, Huo-Lan& Dong, Min& Zhang, Qian& Wang, Fang. Thymoquinone Protects against Hyperlipidemia-Induced Cardiac Damage in Low-Density Lipoprotein Receptor-Deficient (LDL-R--) Mice via Its Anti-inflammatory and Antipyroptotic Effects. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1134279
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134279
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر