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Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Lee, Jung Soo
Ahn, Young-Ho
Sun, Der Sheng
Kim, Yeo Hyung
Won, Hye Sung
Ko, Yoon Ho
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-22
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background/Aims.
The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition.
However, the potential prognostic value of miR-200s in various human malignancies remains controversial.
This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors.
Methods.
Eligible published studies were identified by searching the Embase, PubMed, CINAHL, and Google scholar databases.
Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association.
Results.
The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [OS]: HR = 0.70, 95% CI 0.54–0.91; progression-free survival [PFS]: HR = 0.63, 95% CI 0.52–0.76) in thirty-four eligible articles.
In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15–2.46; PFS, HR = 2.62, 95% CI 1.68–4.07).
Conclusion.
The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas.
To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lee, Jung Soo& Ahn, Young-Ho& Won, Hye Sung& Sun, Der Sheng& Kim, Yeo Hyung& Ko, Yoon Ho. 2017. Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134324
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lee, Jung Soo…[et al.]. Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1134324
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lee, Jung Soo& Ahn, Young-Ho& Won, Hye Sung& Sun, Der Sheng& Kim, Yeo Hyung& Ko, Yoon Ho. Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1134324
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134324
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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