Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora
المؤلفون المشاركون
Wang, Weihong
Teng, Guigen
Liu, Yun
Wu, Ting
Wang, Huahong
Hu, Fulian
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-08-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
This study explored the therapeutic efficacy of standard triple therapy combined with sucralfate suspension gel as well as the mechanisms of action in mouse models of H.
pylori infection.
Materials and Methods.
C57BL/6J mice were randomly divided into 5 groups: NC (natural control), HP (H.
pylori infection), RAC (rabeprazole, amoxicillin, and clarithromycin), RACS (RAC and sucralfate suspension gel), and RACB (RAC and bismuth potassium citrate).
HE staining and electron microscopy were performed to estimate histological and ultrastructural damages.
The IL-8, IL-10, and TNF-α of gastric antrum tissues were measured by immunohistochemistry and qRT-PCR.
ZO-1 and Occludin were also detected with immunohistochemistry.
The genomes of gastric and fecal microbiota were sequenced.
Results.
The eradication rate of H.
pylori in the RACS group was higher than the RAC group.
RACS therapy had protective effects on H.
pylori-induced histological and ultrastructural damages, which were superior to the RAC group.
RACS therapy reduced the protein and mRNA levels of IL-8 compared with the RAC group.
The expression of Occludin in the RACS group was significantly higher than that of the RAC group.
The composition of gastric and fecal microbiota for RACS was similar to the RACB group according to PCA.
Conclusions.
The RACS regimen eradicated H.
pylori infection effectively and showed RACS had protective effects against H.
pylori-induced histological and ultrastructural damage.
The mechanisms of RACS effects included decreasing IL-8, enhancing Occludin, and transforming gastric microbiota.
Moreover, RACS and RACB have a similar effect on gastrointestinal flora.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Teng, Guigen& Liu, Yun& Wu, Ting& Wang, Weihong& Wang, Huahong& Hu, Fulian. 2020. Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Teng, Guigen…[et al.]. Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1134325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Teng, Guigen& Liu, Yun& Wu, Ting& Wang, Weihong& Wang, Huahong& Hu, Fulian. Efficacy of Sucralfate-Combined Quadruple Therapy on Gastric Mucosal Injury Induced by Helicobacter pylori and Its Effect on Gastrointestinal Flora. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر