Simulating Notch-Dome Morphology of Action Potential of Ventricular Cell: How the Speeds of Positive and Negative Feedbacks on Transmembrane Voltage Can Influence the Health of a Cell?
المؤلفون المشاركون
Sabzpoushan, S. H.
Ghajarjazy, A.
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-04
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Ventricular action potential is well-known because of its plateau phase with a spike-notch-dome morphology.
As such, the morphology of action potential is necessary for ensuring a correct heart functioning.
Any distraction from normal notch-dome morphology may trigger a circus movement reentry in the form of lethal ventricular fibrillation.
When the epicardial action potential dome propagates from a site where it is maintained to regions where it has been lost, it gives rise to the proposed mechanism for the Brugada syndrome.
Despite the impact of notch-dome dynamics on the heart function, no independent and explicit research has been performed on the simulation of notch-dome dynamics and morphology.
In this paper, using a novel mathematical approach, a three-state variable model is proposed; we show that our proposed model not only can simulate morphology of action potential of ventricular cells but also can propose a biological reasonable tool for controlling of the morphology of action potential spike-notch-dome.
We show that the processes of activation and inactivation of ionic gating variables (as positive or negative feedbacks on the voltage of cell membrane) and the ratio of their speeds (time constants) can be treated as a reasonable biological tool for simulating ventricular cell notch-dome.
This finding may led to a new insight to the quantification of the health of a ventricular cell and may also propose a new drug therapy strategy for cardiac diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sabzpoushan, S. H.& Ghajarjazy, A.. 2020. Simulating Notch-Dome Morphology of Action Potential of Ventricular Cell: How the Speeds of Positive and Negative Feedbacks on Transmembrane Voltage Can Influence the Health of a Cell?. BioMed Research International،Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1134540
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sabzpoushan, S. H.& Ghajarjazy, A.. Simulating Notch-Dome Morphology of Action Potential of Ventricular Cell: How the Speeds of Positive and Negative Feedbacks on Transmembrane Voltage Can Influence the Health of a Cell?. BioMed Research International No. 2020 (2020), pp.1-16.
https://search.emarefa.net/detail/BIM-1134540
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sabzpoushan, S. H.& Ghajarjazy, A.. Simulating Notch-Dome Morphology of Action Potential of Ventricular Cell: How the Speeds of Positive and Negative Feedbacks on Transmembrane Voltage Can Influence the Health of a Cell?. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-16.
https://search.emarefa.net/detail/BIM-1134540
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134540
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر