Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers
المؤلفون المشاركون
Zhu, Tengjiao
Chen, Yingtong
Min, Shuyuan
Li, Fang
Tian, Yun
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-21
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The mammalian orosomucoid-like gene family (ORMDL), containing ORMDL1, ORMDL2, and ORMDL3, is the important regulator of sphingolipid metabolism, which is relevant to cell growth, proliferation, migration, and invasion.
Since the role of ORMDL1 in cancers remained unclear, the main purpose of our study was to explore the expression patterns and prognostic values of ORMDL1 in different tumors, especially in cholangiocarcinoma (CHOL), lymphoid neoplasm diffuse large B cell lymphoma (DLBCL), acute myeloid leukemia (LAML), and thymoma (THYM).
Bioinformatics tools including GEPIA, CCLE, LinkedOmics, cBioPortal, and TIMER databases were used.
As a result, the expression levels of ORMDL1 in tumor tissues and normal tissues varied in different cancers, especially significantly upregulated in CHOL, DLBCL, LAML, and THYM.
Moreover, ORMDL1 mRNA was also highly expressed in cell lines of DLBCL and LAML.
Further studies showed that ORMDL1 overexpression was associated with poor prognosis in DLBCL, but not significant in CHOL, LAML, and THYM.
Consistently, there were genetic alterations of ORMDL1 in DLBCL, and patients with genetic alterations indicated worse survival.
Coexpressed genes and related biological events with ORMDL1 in DLBCL were found via LinkedOmics, Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis.
The relationship between ORMDL1 and cancer immune cells was investigated, and ORMDL1 expression was positively correlated with infiltrating levels of B cells.
In conclusion, ORMDL1 is suggested to be a tumorigenic factor and considered as the potential therapeutic target and prognostic biomarker in DLBCL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Tengjiao& Chen, Yingtong& Min, Shuyuan& Li, Fang& Tian, Yun. 2020. Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134548
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Tengjiao…[et al.]. Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1134548
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Tengjiao& Chen, Yingtong& Min, Shuyuan& Li, Fang& Tian, Yun. Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134548
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134548
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر