![](/images/graphics-bg.png)
Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria
المؤلفون المشاركون
Iwasaki, Hironori
Inafuku, Masashi
Taira, Naoyuki
Saito, Seikoh
Oku, Hirosuke
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We identified a nitidine- (NTD-) accumulating organelle and evaluated the net cytotoxicity of accumulated NTD.
To evaluate tumor cell selectivity of the drug, we evaluated its selective cytotoxicity against 39 human cancer cell lines (JFCR39 panel), and the profile was compared with those of known anticancer drugs.
Organelle specificity of NTD was visualized using organelle-targeted fluorescent proteins.
Real-time analysis of cell growth, proliferation, and cytotoxicity was performed using the xCELLigence system.
Selectivity of NTD in the JFCR39 panel was evaluated.
Mitochondria-specific accumulation of NTD was observed.
Real-time cytotoxicity analysis suggested that the mechanism of NTD-induced cell death is independent of the cell cycle.
Short-term treatment indicated that this cytotoxicity only resulted from the accumulation of NTD into the mitochondria.
The results from the JFCR39 panel indicated that NTD-mediated cytotoxicity resulted from unique mechanisms compared with those of other known anticancer drugs.
These results suggested that the cytotoxicity of NTD is only induced by its accumulation in mitochondria.
The drug triggered mitochondrial dysfunction in less than 2 h.
Similarity analysis of the selectivity of NTD in 39 tumor cell lines strongly supported the unique tumor cell specificity of NTD.
Thus, these features indicate that NTD may be a promising antitumor drug for new combination chemotherapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iwasaki, Hironori& Inafuku, Masashi& Taira, Naoyuki& Saito, Seikoh& Oku, Hirosuke. 2017. Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134565
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iwasaki, Hironori…[et al.]. Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134565
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iwasaki, Hironori& Inafuku, Masashi& Taira, Naoyuki& Saito, Seikoh& Oku, Hirosuke. Tumor-Selective Cytotoxicity of Nitidine Results from Its Rapid Accumulation into Mitochondria. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134565
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134565
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)