Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis
المؤلفون المشاركون
Liu, Bowen
Liu, Liwei
Chen, Guanzhong
Li, Huanqiang
Mai, Ziling
Zhang, Liyao
Chen, Shiqun
Chen, Jiyan
Liu, Yong
Li, Min
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Several studies have reported conflicting findings regarding the association between tumor necrosis factor-alpha (TNF-α) genetic polymorphisms and acute kidney injury (AKI).
Therefore, we performed this meta-analysis to further investigate whether TNF-α variants are related to AKI susceptibility.
Methods.
A comprehensive search of observational studies on the association of TNF-α polymorphism with AKI susceptibility was conducted in the PubMed, Cochrane, and Embase databases through February 10, 2020.
Pooled odds ratios (ORs) and 95% corresponding confidence intervals (95% CIs) were analyzed to evaluate the strength of the relationship.
Results.
A total of 8 studies involving 6694 patients (2559 cases and 4135 controls) were included.
Pooled analysis showed a trend of increased risk between the TNF-α rs1800629 variant and AKI (A vs.
G: OR 95%CI=1.33 0.98‐1.81) among the overall population.
Ethnicity-stratified analysis indicated that the TNF-α rs1800629 variant was a risk factor for Asians (OR 95%CI=1.93 1.59‐2.35) while it is not for Caucasians (OR 95%CI=1.04 0.91‐1.20).
Additionally, we also found that TNF-α rs1799964 polymorphism was observed to have a significant relationship with AKI risk in Asian patients (C vs.
T, OR 95%CI=1.26 1.11‐1.43).
Conclusions.
The TNF rs1800629 polymorphism exhibited a trend toward AKI susceptibility with ethnic differences.
The relationship was found to be significant among the Asian population, but not among those of Caucasian origin.
Additionally, the TNF-α rs1799964 polymorphism was also related to a significantly increased risk of AKI in Asians.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Guanzhong& Liu, Bowen& Li, Huanqiang& Mai, Ziling& Zhang, Liyao& Li, Min…[et al.]. 2020. Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134613
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Guanzhong…[et al.]. Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134613
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Guanzhong& Liu, Bowen& Li, Huanqiang& Mai, Ziling& Zhang, Liyao& Li, Min…[et al.]. Ethnicity-Stratified Analysis of the Association between TNF-α Genetic Polymorphisms and Acute Kidney Injury: A Systematic Review and Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134613
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134613
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر