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IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice
المؤلفون المشاركون
Zhang, Zhen-biao
Guo, Ying-fang
Guo, Meng-yao
Liu, Yuzhu
Li, Chengye
Deng, Ganzhen
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-02-26
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S.
aureus-induced endometritis and to elucidate the mechanism of action underlying these effects.
In the present study, the effect of IFN-τ on S.
aureus growth was monitored by turbidimeter at 600 nm.
IFN-τ did not affect S.
aureus growth.
The histopathological changes indicated that IFN-τ had a protective effect on uterus tissues with S.
aureus infection.
The ELISA and qPCR results showed the production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 was decreased with IFN-τ treatment.
In contrast, the level of the anti-inflammatory cytokine IL-10 was increased.
We further studied the signaling pathway associated with these observations, and the qPCR results showed that the expression of TLR2 was repressed by IFN-τ.
Furthermore, the western blotting results showed the phosphorylation of IκB, NF-κB p65, and MAPKs (p38, JNK, and ERK) was inhibited by IFN-τ treatment.
The results suggested that IFN-τ may be a potential drug for the treatment of uterine infection due to S.
aureus or other infectious inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Zhen-biao& Guo, Ying-fang& Liu, Yuzhu& Li, Chengye& Guo, Meng-yao& Deng, Ganzhen. 2017. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Zhen-biao…[et al.]. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Zhen-biao& Guo, Ying-fang& Liu, Yuzhu& Li, Chengye& Guo, Meng-yao& Deng, Ganzhen. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134666
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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