IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice
Joint Authors
Zhang, Zhen-biao
Guo, Ying-fang
Guo, Meng-yao
Liu, Yuzhu
Li, Chengye
Deng, Ganzhen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The aim of the present study was to determine the anti-inflammatory effect of IFN-τ on endometritis using a mouse model of S.
aureus-induced endometritis and to elucidate the mechanism of action underlying these effects.
In the present study, the effect of IFN-τ on S.
aureus growth was monitored by turbidimeter at 600 nm.
IFN-τ did not affect S.
aureus growth.
The histopathological changes indicated that IFN-τ had a protective effect on uterus tissues with S.
aureus infection.
The ELISA and qPCR results showed the production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 was decreased with IFN-τ treatment.
In contrast, the level of the anti-inflammatory cytokine IL-10 was increased.
We further studied the signaling pathway associated with these observations, and the qPCR results showed that the expression of TLR2 was repressed by IFN-τ.
Furthermore, the western blotting results showed the phosphorylation of IκB, NF-κB p65, and MAPKs (p38, JNK, and ERK) was inhibited by IFN-τ treatment.
The results suggested that IFN-τ may be a potential drug for the treatment of uterine infection due to S.
aureus or other infectious inflammatory diseases.
American Psychological Association (APA)
Zhang, Zhen-biao& Guo, Ying-fang& Liu, Yuzhu& Li, Chengye& Guo, Meng-yao& Deng, Ganzhen. 2017. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
Modern Language Association (MLA)
Zhang, Zhen-biao…[et al.]. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
American Medical Association (AMA)
Zhang, Zhen-biao& Guo, Ying-fang& Liu, Yuzhu& Li, Chengye& Guo, Meng-yao& Deng, Ganzhen. IFN-τ Displays Anti-Inflammatory Effects on Staphylococcus aureus Endometritis via Inhibiting the Activation of the NF-κB and MAPK Pathways in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134666
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1134666