CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
المؤلفون المشاركون
Huang, Ling
Xu, Wanfu
Gong, Sitang
Xu, Zhaohui
Liu, Ruitao
Xu, Yuxin
Su, Mingmin
Chen, Jiayu
Geng, Lanlan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Pyroptosis, a novel form of inflammatory programmed cell death, was recently found to be a cause of mucosal barrier defect.
In our pervious study, CD147 expression was documented to increase in intestinal tissue of inflammatory bowel disease (IBD).
Objective.
The aim of this study was to determine the function of serum CD147 in pyroptosis.
Methods.
The study group consisted of 96 cases.
The centration of CD147, IL-1β, and IL-18 levels in serum was assessed by ELISA.
Real-time PCR and WB were performed to analyze the effect of CD147 on pyroptosis.
Results.
In this study, our results showed that CD147 induced cell pyroptosis in intestinal epithelial cells (IECs) by enhancement of IL-1β and IL-18 expression and secretion in IECs, which is attributed to activation of inflammasomes, including caspase-1 and GSDMD as well as GSDME, leading to aggregate inflammatory reaction.
Mechanically, CD147 promoted phosphorylation of NF-κB p65 in IECs, while inhibition of NF-κB activity by the NF-κB inhibitor BAY11-7082 reversed the effect of CD147 on IL-1β and IL-18 secretion.
Most importantly, serum CD147 level is slightly clinically correlated with IL-1β, but not IL-18 level.
Conclusion.
These findings revealed a critical role of CD147 in the patients with IBD, suggesting that blockade of CD147 may be a novel therapeutic strategy for the patients with IBD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Zhaohui& Liu, Ruitao& Huang, Ling& Xu, Yuxin& Su, Mingmin& Gong, Sitang…[et al.]. 2020. CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gong, Sitang…[et al.]. CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1134710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Zhaohui& Liu, Ruitao& Huang, Ling& Xu, Yuxin& Su, Mingmin& Gong, Sitang…[et al.]. CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1134710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر