Application of BERT to Enable Gene Classification Based on Clinical Evidence
المؤلفون المشاركون
Su, Yuhan
Xiang, Hongxin
Xie, Haotian
Yu, Yong
Dong, Shiyan
Yang, Zhaogang
Zhao, Na
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-07
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The identification of profiled cancer-related genes plays an essential role in cancer diagnosis and treatment.
Based on literature research, the classification of genetic mutations continues to be done manually nowadays.
Manual classification of genetic mutations is pathologist-dependent, subjective, and time-consuming.
To improve the accuracy of clinical interpretation, scientists have proposed computational-based approaches for automatic analysis of mutations with the advent of next-generation sequencing technologies.
Nevertheless, some challenges, such as multiple classifications, the complexity of texts, redundant descriptions, and inconsistent interpretation, have limited the development of algorithms.
To overcome these difficulties, we have adapted a deep learning method named Bidirectional Encoder Representations from Transformers (BERT) to classify genetic mutations based on text evidence from an annotated database.
During the training, three challenging features such as the extreme length of texts, biased data presentation, and high repeatability were addressed.
Finally, the BERT+abstract demonstrates satisfactory results with 0.80 logarithmic loss, 0.6837 recall, and 0.705 F-measure.
It is feasible for BERT to classify the genomic mutation text within literature-based datasets.
Consequently, BERT is a practical tool for facilitating and significantly speeding up cancer research towards tumor progression, diagnosis, and the design of more precise and effective treatments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Su, Yuhan& Xiang, Hongxin& Xie, Haotian& Yu, Yong& Dong, Shiyan& Yang, Zhaogang…[et al.]. 2020. Application of BERT to Enable Gene Classification Based on Clinical Evidence. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134822
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Su, Yuhan…[et al.]. Application of BERT to Enable Gene Classification Based on Clinical Evidence. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134822
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Su, Yuhan& Xiang, Hongxin& Xie, Haotian& Yu, Yong& Dong, Shiyan& Yang, Zhaogang…[et al.]. Application of BERT to Enable Gene Classification Based on Clinical Evidence. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134822
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134822
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر