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Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis
المؤلفون المشاركون
Chen, Zhen
Liu, Genglong
Peng, Rui
Liang, Xingzhong
Zhang, Gang
Yao, Yuan
Pan, Xiaojuan
Wang, Jinshan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-08
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Background.
Previous studies have investigated the association between the use of bisphosphonates and the development of breast cancer, which presented controversial results.
Thus, this meta-analysis was conducted to summarize the current evidence of the association of bisphosphonate use with breast cancer risk.
Methods.
A comprehensive search was conducted in PubMed, ISI Web of Knowledge, the Cochrane Library, and Embase from inception to March 2019 by two researches, who independently selected trials, retrieved relevant data, and assessed study quality.
The summary relative risk (RR) for the use of bisphosphonates on the risks of developing breast cancer was calculated using a random-effect model.
Results.
The present meta-analysis, which included four case-control studies, involving 55052 breast cancer cases, and seven retrospective cohort studies, involving 14641 breast cancer cases, assessed the effect of bisphosphonates on breast cancer risk.
The random-effect model meta-analysis found a reduced risk of breast cancer with exposure to bisphosphonates with pooled RR of 0.87 (95% confidence interval [CI]: 0.80 to 0.94).
The short-term use of bisphosphonates (<1 year) did not render significant alteration (RR=0.92, 95% CI: 0.82 to 1.03), while a significant 26% risk reduction of breast cancer was noted with long-term use (>1 year) (RR=0.74, 95% CI: 0.62 to 0.90).
A protective effect of bisphosphonates was shown in contralateral breast cancer (RR=0.41, 95% CI: 0.20 to 0.84).
In terms of the type of bisphosphonates, a significant inverse relationship was noted for etidronate, with pooled RR of 0.87 (95% CI: 0.80 to 0.96).
Conclusion.
This meta-analysis suggested that the use of bisphosphonates was associated with reduced risk of breast cancer, including contralateral breast cancer.
Compared to other types of bisphosphonates, only etidronate showed a significant inverse relationship.
Additionally, the long-term use (>1 year) of bisphosphonates was more significant in lowering breast cancer risk.
Further randomized controlled trials are needed to verify this association.
This trial is registered with PROSPERO (registration number: CRD42018105024) (registered on 29 August 2018).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Rui& Liang, Xingzhong& Zhang, Gang& Yao, Yuan& Chen, Zhen& Pan, Xiaojuan…[et al.]. 2020. Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Rui…[et al.]. Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1134829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Rui& Liang, Xingzhong& Zhang, Gang& Yao, Yuan& Chen, Zhen& Pan, Xiaojuan…[et al.]. Association Use of Bisphosphonates with Risk of Breast Cancer: A Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1134829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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