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Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice
المؤلفون المشاركون
Qian, Wei
Wang, Liyun
Tu, Lei
Zhang, Jinping
Xu, Keshu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To study the pathogenic feature of liver injury, activation of hepatic stellate cells, and dynamic expression of TGF-β1/TGF-β3 to reveal their role in liver injury induced by ConA.
Methods.
Mice were randomly divided into control group and ConA treatment group.
ConA (20 mg/kg) was injected through vena caudalis in ConA treatment group; the controls received the same volume of saline injection.
After injection for 2 h, 8 h, 24 h, and 48 h, animals were terminated.
Blood, liver, and spleen were harvested.
Liver function and histopathology were studied.
α-SMA, vimentin, TGF-β1, and TGF-β3 were detected.
Results.
After ConA injection, liver damage started to increase.
Expression of α-SMA, vimentin, TGF-β1, and TGF-β3 was significantly enhanced; all above indicators reached peak at 8 h; but from 24 h after ConA injection, TGF-β3 expression began to decline, while the TGF-β1/TGF-β3 ratio at 48 h was significantly lower than control.
Conclusion.
(1) Autoimmune liver injury induced by ConA showed time-based features, in which the most serious liver lesions happened at 8 h after ConA injection.
(2) Early activation of HSC and imbalance expression of TGF-β1 and TGF-β3 existed in ConA-induced acute autoimmune liver injury, which may be associated with liver dysfunction and the mechanisms of progression to fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liyun& Tu, Lei& Zhang, Jinping& Xu, Keshu& Qian, Wei. 2017. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liyun…[et al.]. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liyun& Tu, Lei& Zhang, Jinping& Xu, Keshu& Qian, Wei. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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