Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice
المؤلفون المشاركون
Qian, Wei
Wang, Liyun
Tu, Lei
Zhang, Jinping
Xu, Keshu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
To study the pathogenic feature of liver injury, activation of hepatic stellate cells, and dynamic expression of TGF-β1/TGF-β3 to reveal their role in liver injury induced by ConA.
Methods.
Mice were randomly divided into control group and ConA treatment group.
ConA (20 mg/kg) was injected through vena caudalis in ConA treatment group; the controls received the same volume of saline injection.
After injection for 2 h, 8 h, 24 h, and 48 h, animals were terminated.
Blood, liver, and spleen were harvested.
Liver function and histopathology were studied.
α-SMA, vimentin, TGF-β1, and TGF-β3 were detected.
Results.
After ConA injection, liver damage started to increase.
Expression of α-SMA, vimentin, TGF-β1, and TGF-β3 was significantly enhanced; all above indicators reached peak at 8 h; but from 24 h after ConA injection, TGF-β3 expression began to decline, while the TGF-β1/TGF-β3 ratio at 48 h was significantly lower than control.
Conclusion.
(1) Autoimmune liver injury induced by ConA showed time-based features, in which the most serious liver lesions happened at 8 h after ConA injection.
(2) Early activation of HSC and imbalance expression of TGF-β1 and TGF-β3 existed in ConA-induced acute autoimmune liver injury, which may be associated with liver dysfunction and the mechanisms of progression to fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Liyun& Tu, Lei& Zhang, Jinping& Xu, Keshu& Qian, Wei. 2017. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Liyun…[et al.]. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Liyun& Tu, Lei& Zhang, Jinping& Xu, Keshu& Qian, Wei. Stellate Cell Activation and Imbalanced Expression of TGF-β1TGF-β3 in Acute Autoimmune Liver Lesions Induced by ConA in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1134880
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134880
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر