Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets
المؤلفون المشاركون
Ciavardelli, Domenico
Bellomo, Maria
Consalvo, Ada
Crescimanno, Caterina
Vella, Veronica
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Thyroid cancer (TC) is the most frequent endocrine tumor with a growing incidence worldwide.
Besides the improvement of diagnosis, TC increasing incidence is probably due to environmental factors and lifestyle modifications.
The actual diagnostic criteria for TC classification are based on fine needle biopsy (FNAB) and histological examination following thyroidectomy.
Since in some cases it is not possible to make a proper diagnosis, classical approach needs to be supported by additional biomarkers.
Recently, new emphasis has been given to the altered cellular metabolism of proliferating cancer cells which require high amount of glucose for energy production and macromolecules biosynthesis.
Also TC displays alteration of energy metabolism orchestrated by oncogenes activation and tumor suppressors inactivation leading to abnormal proliferation.
Furthermore, TC shows significant metabolic heterogeneity within the tumor microenvironment and metabolic coupling between cancer and stromal cells.
In this review we focus on the current knowledge of metabolic alterations of TC and speculate that targeting TC metabolism may improve current therapeutic protocols for poorly differentiated TC.
Future studies will further deepen the actual understandings of the metabolic phenotype of TC cells and will give the chance to provide novel prognostic biomarkers and therapeutic targets in tumors with a more aggressive behavior.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ciavardelli, Domenico& Bellomo, Maria& Consalvo, Ada& Crescimanno, Caterina& Vella, Veronica. 2017. Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134894
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ciavardelli, Domenico…[et al.]. Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1134894
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ciavardelli, Domenico& Bellomo, Maria& Consalvo, Ada& Crescimanno, Caterina& Vella, Veronica. Metabolic Alterations of Thyroid Cancer as Potential Therapeutic Targets. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1134894
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134894
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر