The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors
المؤلفون المشاركون
Ksiazek, Krzysztof
Mikuła-Pietrasik, Justyna
Szpurek, Dariusz
Uruski, Paweł
Tykarski, Andrzej
Szubert, Sebastian
Maksin, Konstantin
Moszyński, Rafał
Woźniak, Aldona
Sajdak, Stefan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Here we examined whether malignant ascites may determine ovarian tumor angiogenesis, and if so whether ascites generated by highly aggressive serous and undifferentiated cancers are more proangiogenic than those from less aggressive clear cell and endometrioid tumors.
Angiogenesis was analyzed according to expression of CD31, CD34, and connexin 43.
Proliferation and migration of endothelial cells were tested using fluorescence-based methods.
The quantification of angiogenic agents and hypoxia-inducible factor 1α (HIF-1α) was performed using specific immunoassays.
Results showed that the expression of CD31 and CD34 in serous and undifferentiated tumors was greater, whereas endothelial expression of connexin 43 was lower than in clear cell and endometrioid lesions.
Serous cancers that formed in the presence of ascites displayed increased expression of connexin 43 in vascular smooth muscles as compared with tumors developed in the fluid’s absence.
Endothelial cells exposed to ascites from serous and undifferentiated tumors proliferated and migrated more vigorously than cells subjected to ascites from clear cell and endometrioid cancers.
They also exhibited an increased level of HIF-1α and produced increased amounts of multiple proangiogenic agents.
Our results indicate that high vascularization of aggressive ovarian tumors may be associated with profound angiogenic capabilities of ascites generated by these tumors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mikuła-Pietrasik, Justyna& Uruski, Paweł& Szubert, Sebastian& Maksin, Konstantin& Moszyński, Rafał& Szpurek, Dariusz…[et al.]. 2017. The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors. BioMed Research International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134938
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mikuła-Pietrasik, Justyna…[et al.]. The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors. BioMed Research International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1134938
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mikuła-Pietrasik, Justyna& Uruski, Paweł& Szubert, Sebastian& Maksin, Konstantin& Moszyński, Rafał& Szpurek, Dariusz…[et al.]. The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1134938
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134938
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر