Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses
المؤلفون المشاركون
Chen, Biao
Li, Peishan
Li, Jun
Chen, Jinping
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-29
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Acne is the eighth most common disease worldwide.
Disease burden of acne such as anxiety, reduced self-esteem, and facial scarring lowers the life quality of acne patients.
Isotretinoin is the most potent treatment for moderate-severe acne.
However, the adverse events of isotretinoin especially teratogenicity limit its use.
This study aims at investigating the therapeutical mechanisms of isotretinoin using bioinformatics analysis.
Differentially expressed genes (DEGs) were filtered from microarray datasets GSE10432, GSE10433, and GSE11792.
Functional and pathway enrichment analyses of DEGs were performed.
Protein–protein interaction (PPI) network and module analyses were also conducted based on DEGs.
Using isotretinoin for 1 week, LCN2, PTGES, and GDF15 were upregulated and might mediate sebocytes apoptosis and thus decreased sebum production; CCL2 originated from activated TNF signaling pathway and S100A7 could be related with “acne-flare”.
While treating with isotretinoin for 8 weeks, key genes were downregulated, including HMGCS1, HMGCR, FDFT1, MVD, IDI1, and FDPS, which may be associated with decreased sebum synthesis; HMGCS1, HMGCR, and FDFT1 also probably associated with apoptosis of sebocytes.
There were only two common genes including ACSBG1 and BCAT2 which worked in both 1 week and 8 weeks and could associate with decreased sebum synthesis and apoptosis of sebocytes, respectively.
These results indicate potential therapeutics and side effect mechanisms of isotretinoin in the acne treatment and provide a research direction to further investigate the therapeutic mechanism of isotretinoin and thus develop retinoid-like compounds with similar curative effect and without teratogenicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Biao& Li, Peishan& Li, Jun& Chen, Jinping. 2020. Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses. BioMed Research International،Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134984
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Biao…[et al.]. Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses. BioMed Research International No. 2020 (2020), pp.1-14.
https://search.emarefa.net/detail/BIM-1134984
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Biao& Li, Peishan& Li, Jun& Chen, Jinping. Putative Genes and Pathways Involved in the Acne Treatment of Isotretinoin via Microarray Data Analyses. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-14.
https://search.emarefa.net/detail/BIM-1134984
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1134984
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر