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Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology
المؤلفون المشاركون
Yang, Liangjun
Li, Haiwen
Yang, Maoyi
Zhang, Weijian
Li, Mianli
Xu, Yifei
Li, Jingwei
Kang, Jianyuan
Zhang, Jingchao
Guo, Shaoju
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-10-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Kaempferol is a natural polyphenol in lots of Chinese herbs, which has shown promising treatment for gastric cancer (GC).
However, the molecular mechanisms of its action have not been systematically revealed yet.
In this work, a network pharmacology approach was used to elucidate the potential mechanisms of kaempferol in the treatment of GC.
Methods.
The kaempferol was input into the PharmMapper and SwissTargetPrediction database to get its targets, and the targets of GC were obtained by retrieving the Online Mendelian Inheritance in Man (OMIM) database, MalaCards database, Therapeutic Target Database (TTD), and Coolgen database.
The molecular docking was performed to assess the interactions between kaempferol and these targets.
Next, the overlap targets of kaempferol and GC were identified for GO and KEGG enrichment analyses.
Afterward, a protein-protein interaction (PPI) network was constructed to get the hub targets, and the expression and overall survival analysis of the hub target were investigated.
Finally, the overall survival (OS) analysis of hub targets was performed using the Kaplan-Meier Plotter online tool.
Results.
A total of 990 genes related to GC and 10 overlapping genes were determined through matching the 24 potential targets of kaempferol with disease-associated genes.
The result of molecular docking indicated that kaempferol can bind with these hub targets with good binding scores.
These targets were further mapped to 140 GO biological process terms and 11 remarkable pathways.
In the PPI network analysis, 3 key targets were identified, including ESR1, EGFR, and SRC.
The mRNA and protein expression levels of EGFR and SRC were obviously higher in GC tissues.
High expression of these targets was related to poor OS in GC patients.
Conclusions.
This study provided a novel approach to reveal the therapeutic mechanisms of kaempferol on GC, which will ease the future clinical application of kaempferol in the treatment of GC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Liangjun& Li, Haiwen& Yang, Maoyi& Zhang, Weijian& Li, Mianli& Xu, Yifei…[et al.]. 2020. Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1135070
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Liangjun…[et al.]. Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1135070
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Liangjun& Li, Haiwen& Yang, Maoyi& Zhang, Weijian& Li, Mianli& Xu, Yifei…[et al.]. Exploration in the Mechanism of Kaempferol for the Treatment of Gastric Cancer Based on Network Pharmacology. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1135070
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135070
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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