Circulating level of serum chemerin and CRP in type 2 diabetes mellitus patients with and without hypertension in menopauses Women

الملخص EN

Chemerin may play a role in connecting inflammation and metabolic syndrome(MS), C-reactive protein(CRP) level is markedly rising during infectious and inflammatory diseases .

The aimed of this study to evaluate both C- reactive protein (CRP) and Chemerin as subclinical markers in diabetic patients women.

A total of 90 women, including, 24 healthy women (as control group), 66 women patients with diabetes mellitus type 2 (T2DM) (22diabetics with hypertension, 22 diabetics without hypertension and 22 hypertension only),there ages ranged between49-64 years.

The result showed that significant increase (p≤0.05) in mean chemerin level in the diabetes group (8.766 ±0.648 ng/ml) in comparison with control group( 4.042±0.320 ng/ml).

Also, the result, revealed that significant increase (P<0.05) in the level of chemerin in women suffering from hypertension and diabetes (14.108 ± 0.577 ng/ml) in comparison to the women suffering from diabetic only which reached (8.766 ± 0.648 ng/ml).

The data pointed out that the serum CRP level significant increase in T2DM group (6.176±0.1905) compared with control group (2.20±0.15 ng/ml) .

Also, the result revealed that significant increase (P<0.05) of the CRP level with hypertension women patients (4.45 ± 0.131ng/ml) compared with the control group( 2.20±0.15 ng/ml) and significant increase(P<0.05) in diabetic with hypertension women group patients comparison with the women suffering from diabetic only.

The chemerin and C-RP in hypertensive and normotensive patients with T2DM may be play an important role in activation of Immune Response in these patients .-