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circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107BDNF Signaling Pathway
المؤلفون المشاركون
Hong, Weijun
Gao, Xiwen
Zhang, Yajuan
Ding, Jingyi
Yang, Qilian
Xie, Haixiang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-09-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Circular RNAs (circRNAs) act as a crucial part in many human diseases, particularly in cancers.
circRNA HIPK3 (circHIPK3) is a special circRNA that may participate in the oncogenesis of non-small-cell lung cancer (NSCLC), even though its latent regulatory mechanism is not very clear.
Here, we studied the roles of circHIPK3 in NSCLC.
qRT-PCR assay was applied to study the expression of circHIPK3 in NSCLC.
The influence of circHIPK3 on NSCLC was estimated by silencing circHIPK3 and miR-107 mock transfection and brain-derived neurotrophic factor (BDNF) overexpression, and the correlation between circHIPK3, miR-107, and BDNF was evaluated by dual-luciferase reporter assay.
The results showed that circHIPK3 expression was upregulated in NSCLC cells.
circHIPK3 knockdown inhibited the migration and proliferation of NSCLC cells by promoting the expression of miR-107.
circHIPK3 could be used as a miR-107 sponge to promote BDNF cell proliferation.
The dual-luciferase reporter assay proved that miR-107 was the target of circHIPK3, and miR-107 had an interaction with the 3′untranslated region of BDNF.
miR-107 overexpression inhibited BDNF-mediated NSCLC cell proliferation.
These results indicate that circHIPK3 promotes tumor progression through a new circHIPK3/miR-107/BDNF axis, which offers potential markers and medical treatment for NSCLC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hong, Weijun& Zhang, Yajuan& Ding, Jingyi& Yang, Qilian& Xie, Haixiang& Gao, Xiwen. 2020. circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107BDNF Signaling Pathway. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135476
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hong, Weijun…[et al.]. circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107BDNF Signaling Pathway. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1135476
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hong, Weijun& Zhang, Yajuan& Ding, Jingyi& Yang, Qilian& Xie, Haixiang& Gao, Xiwen. circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107BDNF Signaling Pathway. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1135476
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135476
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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