Characterizations of Gene Alterations in Melanoma Patients from Chinese Population
المؤلفون المشاركون
Luo, Yi
Zhang, Zhenzhen
Liu, Jianfan
Li, Linqing
Xu, Xuezheng
Yao, Xinyu
Dai, Zixun
Wang, Xin
Yang, Shuo
Wu, Hongwei
Bu, Jie
Wu, Yuan
Xiang, Tianmin
Li, Xianan
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Melanoma is a human skin malignant tumor with high invasion and poor prognosis.
The limited understanding of genomic alterations in melanomas in China impedes the diagnosis and therapeutic strategy selection.
We conducted comprehensive genomic profiling of melanomas from 39 primary and metastatic formalin-fixed paraffin-embedded (FFPE) samples from 27 patients in China based on an NGS panel of 223 genes.
No significant difference in gene alterations was found between primary and metastasis melanomas.
The status of germline mutation, CNV, and somatic mutation in our cohort was quite different from that reported in Western populations.
We further delineated the mutation patterns of 4 molecular subgroups (BRAF, RAS, NF1, and Triple-WT) of melanoma in our cohort.
BRAF mutations were more frequently identified in melanomas without chromic sun-induced damage (non-CSD), while RAS mutations were more likely observed in acral melanomas.
NF1 and Triple-WT subgroups were unbiased between melanomas arising in non-CSD and acral skin.
BRAF, RAS, and NF1 mutations were significantly associated with lymph node metastasis or presence of ulceration, implying that these cancer driver genes were independent prognostic factors.
In summary, our results suggest that mutational profiles of malignant melanomas in China are significantly different from Western countries, and both gene mutation and amplification play an important role in the development and progression of melanomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Yi& Zhang, Zhenzhen& Liu, Jianfan& Li, Linqing& Xu, Xuezheng& Yao, Xinyu…[et al.]. 2020. Characterizations of Gene Alterations in Melanoma Patients from Chinese Population. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135494
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Yi…[et al.]. Characterizations of Gene Alterations in Melanoma Patients from Chinese Population. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135494
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Yi& Zhang, Zhenzhen& Liu, Jianfan& Li, Linqing& Xu, Xuezheng& Yao, Xinyu…[et al.]. Characterizations of Gene Alterations in Melanoma Patients from Chinese Population. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135494
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135494
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر