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Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat
المؤلفون المشاركون
Xu, Sheng-Fei
Du, Guang-Hui
Abulikim, Kuerbanjiang
Cao, Peng
Tan, Hui-bing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objectives.
To evaluate the effects of pentobarbital dosages on lower urinary tract function and to define an appropriate dosage of sodium pentobarbital that would be suitable for urodynamic studies in which recovery from anesthesia and long term survive were needed for subsequent experiment.
Methods.
Twenty-four 8-week-old, female, virgin, Sprague-Dawley rats (200-250 g) were used in this study.
Rats in study groups received gradient doses of pentobarbital intraperitoneally, and those in the control group received urethane intraperitoneally.
External urethral sphincter electromyography (EUS-EMG) was recorded simultaneously during cystometry and leak point pressure tests.
The toe-pinch reflex was used to determine the level of anesthesia.
Results.
Micturition was normally induced in both the urethane group and 32 mg/kg pentobarbital group.
However, in groups of 40 mg/kg or 36 mg/kg pentobarbital, micturition failed to be induced; instead, nonvoiding contractions accompanied by EUS-EMG tonic activity were observed.
There were no significant differences in leak point pressure or EUS-EMG amplitude or frequency between the urethane and 32 mg/kg pentobarbital groups.
Conclusions.
This study confirmed significant dose-dependent effects of pentobarbital on lower urinary tract function and 32 mg/kg pentobarbital as an appropriate dosage for recovery urodynamic testing, which enable the achievement of expected essential micturition under satisfactory anesthesia in female rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Sheng-Fei& Du, Guang-Hui& Abulikim, Kuerbanjiang& Cao, Peng& Tan, Hui-bing. 2020. Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135508
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Sheng-Fei…[et al.]. Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135508
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Sheng-Fei& Du, Guang-Hui& Abulikim, Kuerbanjiang& Cao, Peng& Tan, Hui-bing. Verification and Defined Dosage of Sodium Pentobarbital for a Urodynamic Study in the Possibility of Survival Experiments in Female Rat. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135508
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135508
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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