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Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach
المؤلفون المشاركون
Nugraha, Rivo YB.
Faratisha, Icha FD.
Mardhiyyah, Kana
Ariel, Dio G.
Putri, Fitria F.
Nafisatuzzamrudah, Fitria F.
Winarsih, Sri
Sardjono, Teguh Wahju
Fitri, Loeki Enggar
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-01-09
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Malaria is one of the life-threatening diseases in the world.
The spread of resistance to antimalarial drugs is a major challenge, and resistance to artemisinin has been reported in the Southeast Asian region.
In the previous study, the active compound of Streptomyces hygroscopicus subsp.
Hygroscopicus (S.
hygroscopicus), eponemycin, has been shown to have antimalarial effects.
To further analyze the effects of other active compounds on the Plasmodium parasite, identifying and analyzing the effectiveness of compounds contained in S.
hygroscopicus through instrumentation of liquid chromatography/mass spectrometry (LC/MS) and in silico studies were very useful.
This study aimed at identifying other derivative compounds from S.
hygroscopicus and screening the antimalarial activity of the compound by assessing the binding affinity, pharmacokinetic profile, and bond interaction.
The derivative compounds were identified using LC/MS.
Protein targets for derivative compounds were found through literature studies, and the results of identification of compounds and protein targets were reconstructed into three-dimensional models.
Prediction of pharmacokinetic profiles was carried out using Swiss ADME.
Screening of protein targets for the derivative compound was carried out using the reverse molecular docking method.
Analyzing bond interaction was done by LigPlot.
One compound from S.
hygroscopicus, i.e., 6,7-dinitro-2-[1, 2, 4]triazole-4-yl-benzo[de]isoquinoline-1,3-dione, was successfully identified using LC/MS.
This compound was an isoquinoline derivative compound.
Through literature studies with inclusion criteria, thirteen protein targets were obtained for reverse molecular docking.
This isoquinoline derivative had the potential to bind to each protein target.
The pharmacokinetic profile showed that this compound had the drug-likeness criteria.
Conclusion.
6,7-Dinitro-2-[1, 2, 4]triazole-4-yl-benzo[de]isoquinoline-1,3-dione has antimalarial activity as shown by reverse molecular docking studies and pharmacokinetic profiles.
The best inhibitory ability of compounds based on bond affinity is with adenylosuccinate synthetase.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nugraha, Rivo YB.& Faratisha, Icha FD.& Mardhiyyah, Kana& Ariel, Dio G.& Putri, Fitria F.& Nafisatuzzamrudah, Fitria F.…[et al.]. 2020. Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach. BioMed Research International،Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1135528
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nugraha, Rivo YB.…[et al.]. Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach. BioMed Research International No. 2020 (2020), pp.1-15.
https://search.emarefa.net/detail/BIM-1135528
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nugraha, Rivo YB.& Faratisha, Icha FD.& Mardhiyyah, Kana& Ariel, Dio G.& Putri, Fitria F.& Nafisatuzzamrudah, Fitria F.…[et al.]. Antimalarial Properties of Isoquinoline Derivative from Streptomyces hygroscopicus subsp. Hygroscopicus: An In Silico Approach. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-15.
https://search.emarefa.net/detail/BIM-1135528
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135528
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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