Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury
المؤلفون المشاركون
Dzietko, Mark
Felderhoff-Mueser, Ursula
Bendix, Ivo
Herz, Josephine
Klöfers, Melanie
Kohaut, Jules
Boos, Vinzenz
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Hypoxia ischemia (HI) to the developing brain occurs in 1–6 in 1000 live births.
Large numbers of survivors have neurological long-term sequelae.
However, mechanisms of recovery after HI are not understood and preventive measures or clinical treatments are not effective.
Poly(ADP-ribose) polymerase-1 is overactivated in response to ischemia.
In neonatal mice HI activates PARP-1 but its role in perinatal brain injury remains uncertain.
Objective.
Aim of this study was to explore the effect of TES448 (PARP-1-inhibitor) and hypothermia after an ischemic insult.
Design and Methods.
10-day-old Wistar rats underwent HI.
TES448 was given 10 min, 3 hrs, and 6 hrs after hypoxia.
Hypothermia was started 30 min after HI and brains were dissected at P12.
Western blotting and histological staining were used to evaluate for degree of injury.
Results.
Protein expression of PARP-1 levels was diminished after TES448 treatment.
Cresyl violet and TUNEL staining revealed decreased injury in male rat pups following TES448 and combined treatment.
Female rats showed increased numbers of TUNEL-positive cells after combined therapy.
TES448 inhibited microglia activation after hypoxic-ischemic injury.
A cellular response including NeuN, Olig2, and MBP was not affected by PARP-1-inhibition.
Conclusions.
Inhibition of PARP-1 and hypothermia lead to an alteration of injury but this effect is sexually dimorphic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klöfers, Melanie& Kohaut, Jules& Bendix, Ivo& Herz, Josephine& Boos, Vinzenz& Felderhoff-Mueser, Ursula…[et al.]. 2017. Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135530
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klöfers, Melanie…[et al.]. Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1135530
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klöfers, Melanie& Kohaut, Jules& Bendix, Ivo& Herz, Josephine& Boos, Vinzenz& Felderhoff-Mueser, Ursula…[et al.]. Effects of Poly(ADP-Ribose) Polymerase-1 Inhibition in a Neonatal Rodent Model of Hypoxic-Ischemic Injury. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135530
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135530
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر