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Construction of a Potential Breast Cancer-Related miRNA-mRNA Regulatory Network
المؤلفون المشاركون
Liu, Xinhong
Tan, Fang
Yi, Ruokun
Yang, Dingyi
Zhao, Xin
Chen, Feng
Li, Fang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-04
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Background.
Breast cancer is a malignant tumor that occurs in the epithelial tissue of the breast gland and has become the most common malignancy in women.
The regulation of the expression of related genes by microRNA (miRNA) plays an important role in breast cancer.
We constructed a comprehensive breast cancer-miRNA-gene interaction map.
Methods.
Three miRNA microarray datasets (GSE26659, GSE45666, and GSE58210) were obtained from the GEO database.
Then, the R software “LIMMA” package was used to identify differential expression analysis.
Potential transcription factors and target genes of screened differentially expressed miRNAs (DE-miRNAs) were predicted.
The BRCA GE-mRNA datasets (GSE109169 and GSE139038) were downloaded from the GEO database for identifying differentially expressed genes (DE-genes).
Next, GO annotation and KEGG pathway enrichment analysis were conducted.
A PPI network was then established, and hub genes were identified via Cytoscape software.
The expression and prognostic roles of hub genes were further evaluated.
Results.
We found 6 upregulated differentially expressed- (DE-) miRNAs and 18 downregulated DE-miRNAs by analyzing 3 Gene Expression Omnibus databases, and we predicted the upstream transcription factors and downstream target genes for these DE-miRNAs.
Then, we used the GEO database to perform differential analysis on breast cancer mRNA and obtained differentially expressed mRNA.
We found 10 hub genes of upregulated DE-miRNAs and 10 hub genes of downregulated DE-miRNAs through interaction analysis.
Conclusions.
In this study, we have performed an integrated bioinformatics analysis to construct a more comprehensive BRCA-miRNA-gene network and provide new targets and research directions for the treatment and prognosis of BRCA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xinhong& Chen, Feng& Tan, Fang& Li, Fang& Yi, Ruokun& Yang, Dingyi…[et al.]. 2020. Construction of a Potential Breast Cancer-Related miRNA-mRNA Regulatory Network. BioMed Research International،Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1135557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xinhong…[et al.]. Construction of a Potential Breast Cancer-Related miRNA-mRNA Regulatory Network. BioMed Research International No. 2020 (2020), pp.1-18.
https://search.emarefa.net/detail/BIM-1135557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xinhong& Chen, Feng& Tan, Fang& Li, Fang& Yi, Ruokun& Yang, Dingyi…[et al.]. Construction of a Potential Breast Cancer-Related miRNA-mRNA Regulatory Network. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-18.
https://search.emarefa.net/detail/BIM-1135557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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