![](/images/graphics-bg.png)
Hypoxic Exposure Increases Energy Expenditure by Increasing Carbohydrate Oxidation in Mice
المؤلفون المشاركون
Park, Yeram
Hwang, Deunsol
Park, Hun-Young
Kim, Jisu
Lim, Kiwon
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-06-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aims.
Hypoxic exposure improves glucose metabolism.
We investigated to validate the hypothesis that carbohydrate (CHO) oxidation could increase in mice exposed to severe hypoxic conditions.
Methods.
Seven-week-old male ICR mice (n=16) were randomly divided into two groups: the control group (CON) was kept in normoxic condition (fraction of inspired O2=21%) and the hypoxia group (HYP) was exposed to hypoxic condition (fraction of inspired O2=12%, ≈altitude of 4,300 m).
The CON group was pair-fed with the HYP group.
After 3 weeks of hypoxic exposure, we measured respiratory metabolism (energy expenditure and substrate utilization) at normoxic conditions for 24 hours using an open-circuit calorimetry system.
In addition, we investigated changes in carbohydrate mechanism-related protein expression, including hexokinase 2 (HK2), pyruvate dehydrogenase (PDH), pyruvate dehydrogenase kinase 4 (PDK4), and regulator of the genes involved in energy metabolism (peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PGC1α) in soleus muscle.
Results.
Energy expenditure (EE) and CHO oxidation over 24 hours were higher in the HYP group by approximately 15% and 34% (p<0.001), respectively.
Fat oxidation was approximately 29% lower in the HYP group than the CON group (p<0.01).
Body weight gains were significantly lower in the HYP group than in the CON group (CON vs.
HYP; 1.9±0.9 vs.
−0.3±0.9; p<0.001).
Hypoxic exposure for 3 weeks significantly reduced body fat by approximately 42% (p<0.001).
PDH and PGC1α protein levels were significantly higher in the HYP group (p<0.05).
Additionally, HK2 was approximately 21% higher in the HYP group.
Conclusions.
Hypoxic exposure might significantly enhance CHO oxidation by increasing the expression of PDH and HK2.
This investigation can be useful for patients with impaired glucose metabolism, such as those with type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Yeram& Hwang, Deunsol& Park, Hun-Young& Kim, Jisu& Lim, Kiwon. 2020. Hypoxic Exposure Increases Energy Expenditure by Increasing Carbohydrate Oxidation in Mice. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Yeram…[et al.]. Hypoxic Exposure Increases Energy Expenditure by Increasing Carbohydrate Oxidation in Mice. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Yeram& Hwang, Deunsol& Park, Hun-Young& Kim, Jisu& Lim, Kiwon. Hypoxic Exposure Increases Energy Expenditure by Increasing Carbohydrate Oxidation in Mice. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)