Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis
المؤلفون المشاركون
Wang, Lu
Zhang, Tao
Liu, Yafei
Tang, Fang
Xue, Fuzhong
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-02-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The role of uric acid on metabolic syndrome (MetS) has always been controversial.
This study aims to explore associations between uric acid with MetS and its components in Chinese female health check-up population.
Methods.
1381 subjects constituted the longitudinal health check-up cohort.
Health examination and genotyping were performed.
Unadjusted and adjusted observational analyses were implemented to evaluate observational associations between uric acid with MetS and its components.
Mendelian randomization analysis was performed to estimate the causal effect using variation at rs11722228 (SLC2A9) as an instrument for uric acid.
Results.
An increase of 65% in risk of MetS per standard deviation increase in uric acid was found using unadjusted observational analyses.
This association attenuated on adjustment for potential confounders.
Similar patterns were found in the association analyses of uric acid with hyperglycemia, hypertension, and dyslipidemia.
Neither by performing unadjusted nor adjusted analysis did we see evidence for association of uric acid on overweight and obesity.
Mendelian randomization analyses showed no evidence of causal association between uric acid and MetS and MetS components.
Conclusions.
We found no causal evidence to support that increased serum uric acid is a causal risk factor for MetS or its components.
Hence, there remains no strong evidence for the effeteness of undergoing urate-lowering therapy to prevent the onset of MetS or cardiovascular disease in health management.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lu& Zhang, Tao& Liu, Yafei& Tang, Fang& Xue, Fuzhong. 2020. Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135657
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lu…[et al.]. Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis. BioMed Research International No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1135657
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lu& Zhang, Tao& Liu, Yafei& Tang, Fang& Xue, Fuzhong. Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1135657
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135657
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر