Adipose Extracellular MatrixStromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model
المؤلفون المشاركون
He, Yunfan
Lu, Feng
Sun, Mingliang
Zhou, Tao
Zhang, Pan
Gao, Jianhua
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Mesenchymal stem cells are an attractive cell type for cytotherapy in wound healing.
The authors recently developed a novel, adipose-tissue-derived, injectable extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) for stem cell therapy.
This study was designed to assess the therapeutic effects of ECM/SVF-gel on wound healing and potential mechanisms.
ECM/SVF-gel was prepared for use in nude mouse excisional wound healing model.
An SVF cell suspension and phosphate-buffered saline injection served as the control.
The expression levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and monocyte chemotactic protein-1 (MCP-1) in ECM/SVF-gel were analyzed at different time points.
Angiogenesis (tube formation) assays of ECM/SVF-gel extracts were evaluated, and vessels density in skin was determined.
The ECM/SVF-gel extract promoted tube formation in vitro and increased the expression of the angiogenic factors VEGF and bFGF compared with those in the control.
The expression of the inflammatory chemoattractant MCP-1 was high in ECM/SVF-gel at the early stage and decreased sharply during the late stage of wound healing.
The potent angiogenic effects exerted by ECM/SVF-gel may contribute to the improvement of wound healing, and these effects could be related to the enhanced inflammatory response in ECM/SVF-gel during the early stage of wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Mingliang& He, Yunfan& Zhou, Tao& Zhang, Pan& Gao, Jianhua& Lu, Feng. 2017. Adipose Extracellular MatrixStromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model. BioMed Research International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135744
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Mingliang…[et al.]. Adipose Extracellular MatrixStromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model. BioMed Research International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1135744
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Mingliang& He, Yunfan& Zhou, Tao& Zhang, Pan& Gao, Jianhua& Lu, Feng. Adipose Extracellular MatrixStromal Vascular Fraction Gel Secretes Angiogenic Factors and Enhances Skin Wound Healing in a Murine Model. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1135744
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135744
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر