Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids
المؤلفون المشاركون
Perez-Castillo, Yunierkis
Lima, Tamires C.
Ferreira, Alana R.
Silva, Cecília R.
Campos, Rosana S.
Neto, João B. A.
Magalhães, Hemerson I. F.
Cavalcanti, Bruno C.
Júnior, Hélio V. N.
de Sousa, Damião Pergentino
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-05-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Over the last decade, there has been a dramatic increase in the prevalence and gravity of systemic fungal diseases.
This study aimed therefore at evaluating the antifungal potential of ester derivatives of benzoic and cinnamic acids from three Candida species.
The compounds were prepared via Fischer esterification, and the antifungal assay was performed by the microdilution method in 96-well microplates for determining the minimal inhibitory concentrations (MICs).
The findings of the antifungal tests revealed that the analogue compound methyl ferulate, methyl o-coumarate, and methyl biphenyl-3-carboxylate displayed an interesting antifungal activity against all Candida strains tested, with MIC values of 31.25-62.5, 62.5-125, and 62.5 μg/ml, respectively.
A preliminary Structure-Activity Relationship study of benzoic and cinnamic acid derivatives has led to the recognition of some important structural requirements for antifungal activity.
The results of molecular docking indicate that the presence of the enoate moiety along with hydroxyl and one methoxy substitution in the phenyl ring has a positive effect on the bioactivity of compound 7 against Candida albicans.
These observations further support the hypothesis that the antifungal activity of compound 7 could be due to its binding to multiple targets, specifically to QR, TS, and ST-PK.
Additional experiments are required in the future to test this hypothesis and to propose novel compounds with improved antifungal activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Perez-Castillo, Yunierkis& Lima, Tamires C.& Ferreira, Alana R.& Silva, Cecília R.& Campos, Rosana S.& Neto, João B. A.…[et al.]. 2020. Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids. BioMed Research International،Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135747
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Perez-Castillo, Yunierkis…[et al.]. Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids. BioMed Research International No. 2020 (2020), pp.1-13.
https://search.emarefa.net/detail/BIM-1135747
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Perez-Castillo, Yunierkis& Lima, Tamires C.& Ferreira, Alana R.& Silva, Cecília R.& Campos, Rosana S.& Neto, João B. A.…[et al.]. Bioactivity and Molecular Docking Studies of Derivatives from Cinnamic and Benzoic Acids. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-13.
https://search.emarefa.net/detail/BIM-1135747
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135747
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر