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Colonic Transit Time and Gut Peptides in Adult Patients with Slow and Normal Colonic Transit Constipation
المؤلفون المشاركون
Riezzo, Giuseppe
Russo, Francesco
Orlando, Antonella
D'Attoma, Benedetta
Chimienti, Guglielmina
Clemente, Caterina
Mammone Rinaldi, Caterina
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate whether pathophysiological differences exist among healthy controls (HC) and patients with slow and normal transit constipation (STC and NTC), we evaluated (1) gastrointestinal (GI) symptoms using validated questionnaires; (2) circulating concentrations of neurotensin, motilin, corticotrophin-releasing factor (CRF), and somatostatin; and (3) possible differences in frequency distribution of the neurotensin rs1800832 A/G and Neurotensin Receptor 1 rs6090453 C/G SNPs.
Methods.
Fifty-one patients with severe functional constipation and 20 HC completed the study.
Symptoms were evaluated by GSRS and Constipaq scoring system.
Plasma concentrations of GI peptides were evaluated by ELISA on fasting and six sequential blood samples after a standard meal.
Genotyping was performed by PCR and endonuclease digestion.
Results.
Symptom profiles largely overlapped between NTC and STC patients.
As for peptide profiles, neurotensin showed lower concentrations at 60 and 90 min in STC versus HC, and motilin showed throughout the curve 85% and 82% lower levels in STC than HC and NTC, respectively.
Finally, neurotensin polymorphism resulted in being associated with the peptide levels.
Conclusions.
Symptom profile is not a reliable tool to discriminate STC, whilst the GI peptide profiles might help in identifying it.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Riezzo, Giuseppe& Chimienti, Guglielmina& Clemente, Caterina& D'Attoma, Benedetta& Orlando, Antonella& Mammone Rinaldi, Caterina…[et al.]. 2017. Colonic Transit Time and Gut Peptides in Adult Patients with Slow and Normal Colonic Transit Constipation. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Riezzo, Giuseppe…[et al.]. Colonic Transit Time and Gut Peptides in Adult Patients with Slow and Normal Colonic Transit Constipation. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1135807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Riezzo, Giuseppe& Chimienti, Guglielmina& Clemente, Caterina& D'Attoma, Benedetta& Orlando, Antonella& Mammone Rinaldi, Caterina…[et al.]. Colonic Transit Time and Gut Peptides in Adult Patients with Slow and Normal Colonic Transit Constipation. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1135807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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