Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment
المؤلفون المشاركون
Wang, Zhitian
Xu, Huiling
Zhu, Linhai
He, Tianyu
Lv, Wang
Wu, Zhigang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-04-03
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
A survival risk assessment model associated with a lung adenocarcinoma (LUAD) microenvironment was established and evaluated to identify effective independent prognostic factors for LUAD.
Methods.
The public data were downloaded from the TCGA database, and ESTIMATE prediction software was used to score immune cells and stromal cells for tumor purity prediction.
The samples were divided into the high-score group and the low-score group by the median value of the immune score (or stromal score).
The Wilcoxon test was used for differential analysis.
GO and KEGG enrichment analysis of differentially expressed genes (DEGs) was performed using “clusterProfiler” of R package.
Meanwhile, univariate and multivariate regression analysis was performed on DEGs to construct a multivariate Cox risk regression model with variable gene expression levels as independent prognostic factors affecting a tumor microenvironment (TME) and tumor immunity.
Results.
This study found that LUAD patients with high immune cell (stromal cell) infiltration had better prognosis and were in earlier staging.
Functional enrichment analysis revealed that most DEGs were related to the proliferation and activation of immune cells or stromal cells.
A survival prediction model composed of 6 TME-related genes (CLEC17A, TAGAP, ABCC8, BCAN, FLT3, and CCR2) was established, and finally, the 6 feature genes closely related to the prognosis of LUAD were proved.
The AUC value of the ROC curve in this model was 0.7, indicating that the model was reliable.
Conclusion.
Six genes related to the LUAD microenvironment have a predictive prognostic value in LUAD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhitian& Xu, Huiling& Zhu, Linhai& He, Tianyu& Lv, Wang& Wu, Zhigang. 2020. Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment. BioMed Research International،Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135906
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhitian…[et al.]. Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment. BioMed Research International No. 2020 (2020), pp.1-8.
https://search.emarefa.net/detail/BIM-1135906
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhitian& Xu, Huiling& Zhu, Linhai& He, Tianyu& Lv, Wang& Wu, Zhigang. Establishment and Evaluation of a 6-Gene Survival Risk Assessment Model Related to Lung Adenocarcinoma Microenvironment. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-8.
https://search.emarefa.net/detail/BIM-1135906
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1135906
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر