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Expression of Toll-Like Receptors in the Animal Model of Bladder Outlet Obstruction
المؤلفون المشاركون
Niemczyk, Grzegorz
Fus, Lukasz
Czarzasta, Katarzyna
Jesion, Anika
Radziszewski, Piotr
Gornicka, Barbara
Cudnoch-Jedrzejewska, Agnieszka
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-12
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Introduction.
Bladder outlet obstruction (BOO) occurs in more than 20 percent of the adult population and may lead to changes in the structure and function of the bladder.
The main objective of the study was to evaluate the expression of Toll-like receptor 4 (TLR 4) and Toll-like receptor 9 (TLR 9) in the animal model of BOO as potential triggers of the inflammation phase in the bladder.
In addition, the modulating effect of alpha-1 adrenergic antagonist (tamsulosin) on TLR 4 and TLR 9 expression and inflammatory markers was assessed.
Material and Methods.
Thirty-two male, 9-week-old Sprague Dawley rats were randomly divided into 4 groups: SOP—sham-operated rats with a placebo (water); SOB—sham-operated rats with an alpha-1 adrenergic antagonist; BOOP—rats with BOO and a placebo; and BOOB—rats with BOO and an alpha-1 adrenergic antagonist.
The rats were given a placebo or alpha-1 adrenergic antagonist for 15 days.
Next, urine and the bladder were collected from the rats for histopathological and biochemical study.
Results.
Histopathological analysis showed chronic inflammation without acute inflammation in the bladder.
TLR 4 showed positive cytoplasmic reactivity in the urothelium and the smooth muscles of the bladder.
TLR 9 showed positive cytoplasmic reactivity only in the urothelium.
BOO caused an increase in TLR 4 and TLR 9 expression.
Furthermore, treatment with an alpha-1 adrenergic antagonist had no significant effect on TLR 4 and TLR 9 expression in rats with BOO.
BOO caused a significant increase in urine concentration of interleukin 6 (IL-6), while alpha-1 antagonist reduced the urine concentration of IL-6 and the concentration of interleukin 18 (IL-18).
Conclusions.
The results suggest the participation of TLR 4 and TLR 9 receptors in the induction of inflammation in the bladder, which is the first phase in the development of pathophysiological changes in BOO.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Niemczyk, Grzegorz& Fus, Lukasz& Czarzasta, Katarzyna& Jesion, Anika& Radziszewski, Piotr& Gornicka, Barbara…[et al.]. 2020. Expression of Toll-Like Receptors in the Animal Model of Bladder Outlet Obstruction. BioMed Research International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1136051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Niemczyk, Grzegorz…[et al.]. Expression of Toll-Like Receptors in the Animal Model of Bladder Outlet Obstruction. BioMed Research International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1136051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Niemczyk, Grzegorz& Fus, Lukasz& Czarzasta, Katarzyna& Jesion, Anika& Radziszewski, Piotr& Gornicka, Barbara…[et al.]. Expression of Toll-Like Receptors in the Animal Model of Bladder Outlet Obstruction. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1136051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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