C-Reactive Protein +1444CT Polymorphism Is Associated with the Susceptibility to Pulmonary Tuberculosis

الملخص EN

Objective.

The T allele of C-reactive protein (CRP) +1444C/T (rs1130864) polymorphism was associated with increased risk for some inflammatory conditions.

The objective of the study was to explore the association between the CRP +1444C/T polymorphism with the susceptibility to pulmonary tuberculosis (PTB) in a Chinese population.

Methods.

This case-control study enrolled 480 PTB patients and 480 healthy controls.

The CRP +1444C/T polymorphism was determined using Sanger sequencing.

The odds ratio (OR) and 95% confidence interval (CI) were assessed to examine the strength of genetic correlation.

Results.

The genotype and allele frequencies of PTB patients differed from controls (CT vs.

CC, OR=1.924, 95% CI: 1.099-3.371, adjusted P value=0.022; T vs.

C, OR=1.884, 95% CI: 1.085-3.273, adjusted P value=0.024).

Stratified analysis by sex found that PTB patients’ genotype and allele frequencies differed from controls in the male subgroup but not the female subgroup.

Conclusion.

In conclusion, the minor T allele of CRP +1444C/T polymorphism was associated with increased PTB risk.