Prognostic Value of Pretreatment Albumin-to-Alkaline Phosphatase Ratio in Cancer: A Meta-Analysis
المؤلفون المشاركون
Xie, Hailun
Wei, Lishuang
Tang, Shuangyi
Gan, Jialiang
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Recently, it has been reported that the pretreatment albumin-to-alkaline phosphatase ratio (AAPR) is related to the prognosis of various cancers.
The purpose of this systematic review and meta-analysis was to explore the prognostic value of pretreatment AAPR on clinical outcomes in cancer.
Methods.
PubMed, Web of Science, Cochrane Library, and Embase were systematically searched for relevant research before May 2020.
Stata 12 was utilized to extract the data and the characteristics of each study and to generate a pooled hazard ratio (HR) and 95% confidence interval (CI) to assess the relationship between pretreatment AAPR and survival outcomes.
Results.
We included 16 eligible published articles involving 5,716 patients.
We found that low pretreatment AAPR was associated with poor overall survival (HR=2.12, 95% CI: 1.80–2.50, P<0.001), cancer-specific survival (HR=2.89, 95% CI: 1.46–5.71, P<0.001), disease-free survival (HR=1.91, 95% CI: 1.43–2.53, P<0.001), and progression-free survival (HR=1.93, 95% CI: 1.49–2.52, P<0.001).
However, there was no statistical relationship between pretreatment AAPR and recurrence-free survival, distant-metastasis-free survival, or locoregional relapse-free survival.
The correlation between pretreatment AAPR and overall survival did not change significantly when possible confounders were stratified.
The sensitivity analysis showed that this study was reliable.
Conclusions.
Low pretreatment AAPR was significantly associated with adverse clinical outcomes of cancer.
Pretreatment AAPR could be a valuable noninvasive prognostic indicator for cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xie, Hailun& Wei, Lishuang& Tang, Shuangyi& Gan, Jialiang. 2020. Prognostic Value of Pretreatment Albumin-to-Alkaline Phosphatase Ratio in Cancer: A Meta-Analysis. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136081
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xie, Hailun…[et al.]. Prognostic Value of Pretreatment Albumin-to-Alkaline Phosphatase Ratio in Cancer: A Meta-Analysis. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136081
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xie, Hailun& Wei, Lishuang& Tang, Shuangyi& Gan, Jialiang. Prognostic Value of Pretreatment Albumin-to-Alkaline Phosphatase Ratio in Cancer: A Meta-Analysis. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136081
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136081
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر