Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer
المؤلفون المشاركون
Conde-Rodríguez, Ileana
Delgado-López, Guadalupe
Armenta-Castro, Erick
Ramírez-Díaz, Ivonne
Anaya-Ruiz, Maricruz
Gutiérrez-Quiroz, Claudia T.
Flores-Alonso, Juan Carlos
Reyes-Salinas, Salvador
Vazquez-Zamora, Víctor J.
Ceja-Utrera, Francisco J.
Reyes-Leyva, Julio
López-López, Gustavo
Vallejo-Ruiz, Verónica
López-Colombo, Aurelio
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Galectin-4 has been reported to be altered in different cancer types.
Its expression changes have been associated with early recurrence and metastasis.
In cervical cancer (CC), galectin-4 has not been studied.
The aim of the study was to determine the expression level and subcellular localization of galectin-4 in CC tissue and the concentration in the serum of patients with CC.
For the analysis of serum levels of galectin-4, an ELISA assay was performed.
To assess the expression in cervical tissue, immunohistochemical staining was performed.
The results showed that the concentration of galectin-4 in the serum of patients with CC was higher (647.9 pg/ml) than that in the serum of women with normal cytology (382.1 pg/ml).
The immunohistochemical analysis of CC samples showed a higher expression in keratinizing tumor than nonkeratinizing tumors and a trend of increased expression in tumors from patients with advanced clinical stage.
In normal cervical tissue, galectin-4 was detected in the cytoplasm, and in tumor cells, the presence of galectin-4 was also detected in the nucleus, in both adenocarcinoma and squamous cervical cancer.
The increase in serum concentration and different localization in the tumor cells suggest a possible role of galectin-4 in CC development.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Conde-Rodríguez, Ileana& Delgado-López, Guadalupe& Armenta-Castro, Erick& Ramírez-Díaz, Ivonne& Anaya-Ruiz, Maricruz& Gutiérrez-Quiroz, Claudia T.…[et al.]. 2020. Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Conde-Rodríguez, Ileana…[et al.]. Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Conde-Rodríguez, Ileana& Delgado-López, Guadalupe& Armenta-Castro, Erick& Ramírez-Díaz, Ivonne& Anaya-Ruiz, Maricruz& Gutiérrez-Quiroz, Claudia T.…[et al.]. Evaluation of Serum Levels and Expression of Galectin-4 in Cervical Cancer. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر