Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice
المؤلفون المشاركون
Edvinsson, Marie
Tallkvist, Jonas
Nyström-Rosander, Christina
Ilbäck, Nils-Gunnar
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Chlamydia pneumoniae (C.
pneumoniae) may be a mediator in the pathogenesis of atherosclerosis.
For its growth C.
pneumoniae depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown.
C.
pneumoniae-infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40.
Mice had bacteria in the lungs and liver on all days.
Inflammatory markers, chemokine Cxcl2 and interferon-gamma, were not affected in the liver on day 40.
The copper (Cu)/zinc (Zn) ratio in serum, another marker of infection/inflammation, increased on day 4 and tended to increase again on day 40.
The Fe markers, transferrin receptor (TfR), Hepcidin (Hamp1), and ferroportin 1 (Fpn1), increased in the liver on day 4 and then normalized except for TfR that tended to decrease.
TfR responses were similar to Fe in serum that increased on day 4 but tended to decrease thereafter.
In the liver, Fe was increased on day 4 and also on day 40.
The reappearing increases in Cu/Zn on day 40 concomitant with the increase in liver Fe on day 40, even though TfR tended to decrease, and the fact that viable C.
pneumoniae was present in the lungs and liver may indicate the early phase of activation of recurrent infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Edvinsson, Marie& Tallkvist, Jonas& Nyström-Rosander, Christina& Ilbäck, Nils-Gunnar. 2017. Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice. BioMed Research International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Edvinsson, Marie…[et al.]. Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice. BioMed Research International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1136185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Edvinsson, Marie& Tallkvist, Jonas& Nyström-Rosander, Christina& Ilbäck, Nils-Gunnar. Iron Homeostasis in Tissues Is Affected during Persistent Chlamydia pneumoniae Infection in Mice. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1136185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر