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Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction
المؤلفون المشاركون
Xu, Feng
Wu, Huimin
Zhou, Ting
Tian, Lin
Xia, Zhengchao
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
More and more breast cancer patients prefer autologous fat tissue transfer following lumpectomy to maintain perfect female characteristics.
However, the outcome was not satisfactory due to the transplanted fat absorption.
In this study, we prepared two RADA16-I peptide scaffolds with and without tamoxifen.
Both scaffolds were transparent, porous, and hemisphere-shaped.
The hADSCs isolated from liposuction were attached to the scaffold.
The growth inhibition of the hADSCs induced by TAM in 2-demensional (2D) culture was higher than that in TAM-loaded hydrogel scaffold 3D culture (P<0.05); however, the same outcomes were not observed in MCF-7 cells.
Correspondingly, the apoptosis of the hADSCs induced by TAM was significantly increased in 2D culture compared to that in scaffold 3D culture (P<0.05).
Yet the outcomes of the aoptosis in MCF-7 were contrary.
Apoptosis-related protein Bcl-2 was involved in the process.
In vivo experiments showed that both scaffolds formed a round mass after subcutaneous implantation and it retained its shape after being pressed slightly.
The implantation had no effect on the weight and activity of the animals.
The results suggested that TAM-loaded RADA16-I hydrogel scaffolds both provide support for hADSCs cells attachment/proliferation and retain cytotoxic effect on MCF-7 cells, which might be a promising therapeutic breast tissue following lumpectomy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Huimin& Zhou, Ting& Tian, Lin& Xia, Zhengchao& Xu, Feng. 2017. Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136189
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Huimin…[et al.]. Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136189
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Huimin& Zhou, Ting& Tian, Lin& Xia, Zhengchao& Xu, Feng. Self-Assembling RADA16-I Peptide Hydrogel Scaffold Loaded with Tamoxifen for Breast Reconstruction. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136189
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136189
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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