A Study of IL-1β, MMP-3, TGF-β1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population
المؤلفون المشاركون
Deng, Zhantao
Zhao, Jianning
Bao, Ni-Rong
Chen, Wenxiang
Meng, Jia
Qian, Hong
Chen, Shuo
Xu, Haidong
Sun, Wenshuang
Wang, Yiying
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Primary frozen shoulder (PFS) is a common condition of uncertain etiology that is characterized by shoulder pain and restriction of active and passive glenohumeral motions.
The pathophysiology involves chronic inflammation and fibrosis of the joint capsule.
Single nucleotide polymorphisms (SNPs) at IL-1β, MMP3, TGF-β1, and GDF5 have been associated with risk of a variety of inflammatory diseases; however, no studies have examined these SNPs with susceptibility to PFS.
We investigated allele and genotype frequencies of rs1143627 at IL-1β, rs650108 at MMP-3, rs1800469 at TGF-β1, and rs143383 at GDF5 in 42 patients with PFS and 50 healthy controls in a Chinese Han population.
Serum samples from both cohorts were evaluated to determine the expression levels of IL-1β.
We found that the IL-1β rs1143627 CC genotype was associated with a decreased risk of PFS compared to the TT genotype (P=0.022) and that serum IL-1β was expressed at a significantly higher level in the PFS cohort compared to that found in the control group (P<0.001).
Our findings indicated no evidence of an association between rs650108, rs1800469, or rs143383 and PFS.
IL-1β is associated with susceptibility to PFS and may have a role in its pathogenesis in a Chinese Han population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Wenxiang& Meng, Jia& Qian, Hong& Deng, Zhantao& Chen, Shuo& Xu, Haidong…[et al.]. 2017. A Study of IL-1β, MMP-3, TGF-β1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population. BioMed Research International،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Wenxiang…[et al.]. A Study of IL-1β, MMP-3, TGF-β1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population. BioMed Research International No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1136211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Wenxiang& Meng, Jia& Qian, Hong& Deng, Zhantao& Chen, Shuo& Xu, Haidong…[et al.]. A Study of IL-1β, MMP-3, TGF-β1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1136211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر