Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone
المؤلفون المشاركون
Ding, Kefeng
Zhan, Xiaoli
Sun, Xiaobo
Hong, Yonggang
Wang, Yuedong
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
To explore the role of combined detection of carcinoembryonic antigen (CEA) and neutrophil-to-lymphocyte ratio (NLR) in the prognostic assessment of colorectal cancer (CRC).
Methods.
We investigated preoperative NLR and CEA in 125 surgical CRC patients, determined the patients’ thresholds by receiver operating characteristic (ROC) curve analysis, and assessed their prognostic values by Kaplan–Meier curve and Cox regression models.
In addition, we used nomograms of several risk factors to evaluate the risk in survival and predictive accuracy by using Harrell’s concordance index (c-index).
Results.
Results of multivariate analysis showed high NLR, high CEA, and high COCN (combination of CEA and NLR) were significantly correlated with decreased disease-free survival (DFS) [HR: 2.229, 95% CI: 1.012–4.911, and P=0.047; HR: 3.652, 95% CI: 1.630–8.179, and P=0.002; HR: 3.139, 95% CI: 1.800–5.472, and P<0.001].
But high CEA and COCN remained significant only for decreased overall survival (OS) [HR: 3.713, 95% CI: 1.396–9.873, and P=0.009; HR: 3.106, 95% CI: 1.576–6.123, and P=0.001].
High NLR showed higher mortality rates with worse OS (P=0.058), and nomograms containing NLR improved the predictive accuracy.
Area under the curve of COCN was higher than that of CEA or NLR.
Conclusion.
COCN acts as a better independent prognostic biomarker of CRC than NLR or CEA alone.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhan, Xiaoli& Sun, Xiaobo& Hong, Yonggang& Wang, Yuedong& Ding, Kefeng. 2017. Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136423
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhan, Xiaoli…[et al.]. Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136423
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhan, Xiaoli& Sun, Xiaobo& Hong, Yonggang& Wang, Yuedong& Ding, Kefeng. Combined Detection of Preoperative Neutrophil-to-Lymphocyte Ratio and CEA as an Independent Prognostic Factor in Nonmetastatic Patients Undergoing Colorectal Cancer Resection Is Superior to NLR or CEA Alone. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136423
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136423
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر