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The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma
المؤلفون المشاركون
Takakuwa, Teruhito
Otomaru, Ippei
Araki, Taku
Miura, Akiko
Fujitani, Yotaro
Mochizuki, Yasuhide
Miyagi, Yoshimi
Senzaki, Hideto
Yamamura, Ryosuke
المصدر
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-04-28
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Carfilzomib (CFZ) improves progression-free survival for patients with relapsed or refractory multiple myeloma (MM) but has shown higher frequency of cardiovascular adverse events (CVAEs) than other proteasome inhibitors.
We report the first autopsy case of acute death from cardiac failure shortly after administration of carfilzomib.
A 74-year-old female was diagnosed with IgA MM after a 2-year period of smoldering MM.
She was refractory to both bortezomib plus dexamethasone and lenalidomide plus dexamethasone therapies, so she subsequently received CFZ in combination with lenalidomide and dexamethasone.
The day after the start of the therapy, she complained of severe dyspnea with a significant decline in left ventricular ejection fraction.
Her acute cardiac failure rapidly progressed, and she died on day 7 of the start of CFZ.
The autopsy showed invasion of inflammatory cells between the myocardial cells and very little myocardial necrosis.
There was no obvious thrombus in the coronary artery of the heart, and no infarction or amyloid deposition was observed in the myocardium.
Pathological findings of hypersensitivity myocarditis, a drug-induced cardiomyopathy, appeared to agree with this case except for absence of an eosinophilic infiltration of the myocardium.
A CFZ-induced CVAE is generally considered reversible.
However, rapidly progressing fatal heart failure like in our case is rare.
To characterize CFZ-associated CVAE, further case collection is needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takakuwa, Teruhito& Otomaru, Ippei& Araki, Taku& Miura, Akiko& Fujitani, Yotaro& Mochizuki, Yasuhide…[et al.]. 2019. The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma. Case Reports in Hematology،Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136445
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takakuwa, Teruhito…[et al.]. The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma. Case Reports in Hematology No. 2019 (2019), pp.1-5.
https://search.emarefa.net/detail/BIM-1136445
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takakuwa, Teruhito& Otomaru, Ippei& Araki, Taku& Miura, Akiko& Fujitani, Yotaro& Mochizuki, Yasuhide…[et al.]. The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma. Case Reports in Hematology. 2019. Vol. 2019, no. 2019, pp.1-5.
https://search.emarefa.net/detail/BIM-1136445
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136445
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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