Chlamydial Type III Secretion System Needle Protein Induces Protective Immunity against Chlamydia muridarum Intravaginal Infection
المؤلفون المشاركون
Zigangirova, Naylia A.
Koroleva, Ekaterina A.
Gintsburg, Alexandr L.
Kobets, Natalia V.
Shcherbinin, Dmitrii N.
Shmarov, Maxim M.
Tukhvatulin, Amir I.
Logunov, Denis Y.
Naroditsky, Boris S.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-26
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Chlamydia trachomatis imposes serious health problems and causes infertility.
Because of asymptomatic onset, it often escapes antibiotic treatment.
Therefore, vaccines offer a better option for the prevention of unwanted inflammatory sequelae.
The existence of serologically distinct serovars of C.
trachomatis suggests that a vaccine will need to provide protection against multiple serovars.
Chlamydia spp.
use a highly conserved type III secretion system (T3SS) composed of structural and effector proteins which is an essential virulence factor.
In this study, we expressed the T3SS needle protein of Chlamydia muridarum, TC_0037, an ortholog of C.
trachomatis CdsF, in a replication-defective adenoviral vector (AdTC_0037) and evaluated its protective efficacy in an intravaginal Chlamydia muridarum model.
For better immune responses, we employed a heterologous prime-boost immunization protocol in which mice were intranasally primed with AdTC_0037 and subcutaneously boosted with recombinant TC_0037 and Toll-like receptor 4 agonist monophosphoryl lipid A mixed in a squalene nanoscale emulsion.
We found that immunization with TC_0037 antigen induced specific humoral and T cell responses, decreased Chlamydia loads in the genital tract, and abrogated pathology of upper genital organs.
Together, our results suggest that TC_0037, a highly conserved chlamydial T3SS protein, is a good candidate for inclusion in a Chlamydia vaccine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Koroleva, Ekaterina A.& Kobets, Natalia V.& Shcherbinin, Dmitrii N.& Zigangirova, Naylia A.& Shmarov, Maxim M.& Tukhvatulin, Amir I.…[et al.]. 2017. Chlamydial Type III Secretion System Needle Protein Induces Protective Immunity against Chlamydia muridarum Intravaginal Infection. BioMed Research International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1136478
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Koroleva, Ekaterina A.…[et al.]. Chlamydial Type III Secretion System Needle Protein Induces Protective Immunity against Chlamydia muridarum Intravaginal Infection. BioMed Research International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1136478
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Koroleva, Ekaterina A.& Kobets, Natalia V.& Shcherbinin, Dmitrii N.& Zigangirova, Naylia A.& Shmarov, Maxim M.& Tukhvatulin, Amir I.…[et al.]. Chlamydial Type III Secretion System Needle Protein Induces Protective Immunity against Chlamydia muridarum Intravaginal Infection. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1136478
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136478
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر