Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma
المؤلفون المشاركون
Wang, Zhe-Xiang
Ren, Shao-Chun
Chang, Zi-Song
Ren, Jing
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-11-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Osteosarcoma is known as a type of common human bone malignancy, and more therapeutic targets are still required to combat this disease.
In recent years, the involvement of KIF2A in cancer progression has been widely revealed; however, its potential effect on osteosarcoma development remains unknown.
This study is to assess the KIF2A expression levels in human osteosarcoma tissues and explore its potential role in osteosarcoma development.
Methods.
Immunohistochemical (IHC) assays were conducted to evaluate the expression levels of KIF2A in a total of 74 samples of osteosarcoma tissues and adjacent nontumor tissues.
According to the staining intensity in tumor tissues, patients were divided into highly expressed and low expression KIF2A groups.
The possible links between the KIF2A expression and the clinical pathological features were explored and analyzed, and the effects of KIF2A on osteosarcoma cell proliferation, migration, and invasion were detected through colony formation assay, MTT assay, wound closure assay, and transwell assay, respectively.
The effects of KIF2A on tumor growth and metastasis were detected by the use of animal models.
Results.
KIF2A was highly expressed in human osteosarcoma tissues.
Meanwhile, KIF2A was obviously correlated to the tumor size (P=0.001∗) and clinical stage (P=0.014∗) of osteosarcoma patients.
Our results also revealed that the ablation of KIF2A dramatically blocked the proliferation, migration, and invasion capacity of osteosarcoma cells in vitro and blocked tumor growth and metastasis in mice.
Conclusions.
We investigated the involvement of KIF2A in the development and metastasis of osteosarcoma and therefore thought KIF2A as a promising therapeutic target for osteosarcoma treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhe-Xiang& Ren, Shao-Chun& Chang, Zi-Song& Ren, Jing. 2020. Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136486
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhe-Xiang…[et al.]. Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136486
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhe-Xiang& Ren, Shao-Chun& Chang, Zi-Song& Ren, Jing. Identification of Kinesin Family Member 2A (KIF2A) as a Promising Therapeutic Target for Osteosarcoma. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136486
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136486
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر