Tumor Burden and Intraosseous Metabolic Activity as Predictors of Bone Marrow Failure during Radioisotope Therapy in Metastasized Prostate Cancer Patients
المؤلفون المشاركون
Piana, Michele
Campi, C.
Fiz, Francesco
Sahbai, Samine
Weissinger, Matthias
Dittmann, Helmut
Marini, Cecilia
la Fougère, Christian
Sambuceti, Gianmario
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Rationale.
Radium-223-Dichloride (Ra-223) is an alpha-emitter, used to treat bone metastases.
Patients with high metastatic burden and/or with increased trabecular bone uptake could present a higher incidence of hematologic toxicity.
We hypothesized that these two factors are predictors of bone marrow failure.
Material and Methods.
A computer algorithm discriminated between trabecular bone (BVol) and tumor metastases (MVol) within pretherapeutic whole-body skeletal SPECT/CT (N=47).
The program calculated the metastatic invasion percent (INV%) as the MVol/(MVol+BVol) ratio and extracted the BVol mean counts.
BVol counts were correlated to % drop of hemoglobin (Hb), leukocytes (WBC), and platelets (PLT) after 3/6 Ra-223 cycles.
Patient-specific and computational-derived parameters were tested as predictors of hematologic toxicity with MANOVA.
Results.
BVol counts correlated with drop of Hb (R = 0,65, p<0.01) and PLT (R = 0,45, p<0.01).
Appendicular BVol counts showed a better correlation (p<0.05, p<0.01, and p<0.001 for Hb, WBC, and PLT, resp.).
INV% directly correlated with BVol counts (R = 0.68, p<0.001).
At MANOVA, grade III/IV toxicity was predicted by INV% (p<0.01), by long-bone invasion (p<0.005), and by BVol counts (p<0.05).
Conclusions.
In patients with significant bone tumor burden, degree of bone invasion and trabecular bone uptake are predictors of subsequent bone marrow failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fiz, Francesco& Sahbai, Samine& Campi, C.& Weissinger, Matthias& Dittmann, Helmut& Marini, Cecilia…[et al.]. 2017. Tumor Burden and Intraosseous Metabolic Activity as Predictors of Bone Marrow Failure during Radioisotope Therapy in Metastasized Prostate Cancer Patients. BioMed Research International،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136515
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fiz, Francesco…[et al.]. Tumor Burden and Intraosseous Metabolic Activity as Predictors of Bone Marrow Failure during Radioisotope Therapy in Metastasized Prostate Cancer Patients. BioMed Research International No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1136515
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fiz, Francesco& Sahbai, Samine& Campi, C.& Weissinger, Matthias& Dittmann, Helmut& Marini, Cecilia…[et al.]. Tumor Burden and Intraosseous Metabolic Activity as Predictors of Bone Marrow Failure during Radioisotope Therapy in Metastasized Prostate Cancer Patients. BioMed Research International. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1136515
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136515
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر