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Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review
المؤلفون المشاركون
Shaher, Fahmi
Qiu, Hongbin
Wang, Shuqiu
Hu, Yu
Wang, Weiqun
Zhang, Yu
Wei, Yao
AL-ward, Hisham
Abdulghani, Mahfoudh A. M.
Alenezi, Sattam Khulaif
Baldi, Salem
Zhou, Shaobo
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-07-25
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Even with substantial advances in cardiovascular therapy, the morbidity and mortality rates of diabetic cardiomyopathy (DCM) continually increase.
Hence, a feasible therapeutic approach is urgently needed.
Objectives.
This work is aimed at systemically reviewing literature and addressing cell targets in DCM through the possible cardioprotection of G.
lucidum through its antioxidant effects by using the Open Targets Platform (OTP) website.
Methods.
The OTP website version of 19.11 was accessed in December 2019 to identify the studies in DCM involving G.
lucidum.
Results.
Among the 157 cell targets associated with DCM, the mammalian target of rapamycin (mTOR) was shared by all evidence, drug, and text mining data with 0.08 score association.
mTOR also had the highest score association 0.1 with autophagy in DCM.
Among the 1731 studies of indexed PubMed articles on G.
lucidum published between 1985 and 2019, 33 addressed the antioxidant effects of G.
lucidum and its molecular signal pathways involving oxidative stress and therefore were included in the current work.
Conclusion.
mTOR is one of the targets by DCM and can be inhibited by the antioxidative properties of G.
lucidum directly via scavenging radicals and indirectly via modulating mTOR signal pathways such as Wnt signaling pathway, Erk1/2 signaling, and NF-κB pathways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaher, Fahmi& Qiu, Hongbin& Wang, Shuqiu& Hu, Yu& Wang, Weiqun& Zhang, Yu…[et al.]. 2020. Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review. BioMed Research International،Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1136562
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaher, Fahmi…[et al.]. Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review. BioMed Research International No. 2020 (2020), pp.1-20.
https://search.emarefa.net/detail/BIM-1136562
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaher, Fahmi& Qiu, Hongbin& Wang, Shuqiu& Hu, Yu& Wang, Weiqun& Zhang, Yu…[et al.]. Associated Targets of the Antioxidant Cardioprotection of Ganoderma lucidum in Diabetic Cardiomyopathy by Using Open Targets Platform: A Systematic Review. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-20.
https://search.emarefa.net/detail/BIM-1136562
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136562
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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