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Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock
المؤلفون المشاركون
Wu, Yong
Yin, Qigai
Zhang, Xiaobao
Zhu, Pin
Luan, Hengfei
Chen, Ying
المصدر
العدد
المجلد 2020، العدد 2020 (31 ديسمبر/كانون الأول 2020)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2020-12-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Sepsis is a systemic inflammatory syndrome caused by infection with a high incidence and mortality.
Although long noncoding RNAs have been identified to be closely involved in many inflammatory diseases, little is known about the role of lncRNAs in pediatric septic shock.
Methods.
We downloaded the mRNA profiles GSE13904 and GSE4607, of which GSE13904 includes 106 blood samples of pediatric patients with septic shock and 18 health control samples; GSE4607 includes 69 blood samples of pediatric patients with septic shock and 15 health control samples.
The differentially expressed lncRNAs were identified through the limma R package; meanwhile, GO terms and KEGG pathway enrichment analysis was performed via the clusterProfiler R package.
The protein-protein interaction (PPI) network was constructed based on the STRING database using the targets of differently expressed lncRNAs.
The MCODE plug-in of Cytoscape was used to screen significant clustering modules composed of key genes.
Finally, stepwise regression analysis was performed to screen the optimal lncRNAs and construct the logistic regression model, and the ROC curve was applied to evaluate the accuracy of the model.
Results.
A total of 13 lncRNAs which simultaneously exhibited significant differences in the septic shock group compared with the control group from two sets were identified.
According to the 18 targets of differentially expressed lncRNAs, we identified some inflammatory and immune response-related pathways.
In addition, several target mRNAs were predicted to be potentially involved in the occurrence of septic shock.
The logistic regression model constructed based on two optimal lncRNAs THAP9-AS1 and TSPOAP1-AS1 could efficiently separate samples with septic shock from normal controls.
Conclusion.
In summary, a predictive model based on the lncRNAs THAP9-AS1 and TSPOAP1-AS1 provided novel lightings on diagnostic research of septic shock.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yong& Yin, Qigai& Zhang, Xiaobao& Zhu, Pin& Luan, Hengfei& Chen, Ying. 2020. Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock. BioMed Research International،Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136615
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yong…[et al.]. Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock. BioMed Research International No. 2020 (2020), pp.1-9.
https://search.emarefa.net/detail/BIM-1136615
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yong& Yin, Qigai& Zhang, Xiaobao& Zhu, Pin& Luan, Hengfei& Chen, Ying. Long Noncoding RNA THAP9-AS1 and TSPOAP1-AS1 Provide Potential Diagnostic Signatures for Pediatric Septic Shock. BioMed Research International. 2020. Vol. 2020, no. 2020, pp.1-9.
https://search.emarefa.net/detail/BIM-1136615
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1136615
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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